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Induction of iron excess restricts malignant plasma cells expansion and potentiates bortezomib effect in models of multiple myeloma

Leukemia volume 31, pages 967970 (2017) | Download Citation

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Acknowledgements

We thank Giovanni Tonon for the valuable advice. This work was supported by AIRC-Fondazione Cariplo TRIDEO 2014 no. 15465 (to AC) and by AIRC Program Grant in Molecular Oncology-Extension no. 9965 (to AC).

Author contributions

JB performed research, analyzed results and contributed to writing the paper. SG and MTSB performed research. MP performed research and contributed to writing the paper. MC and PLB provided the Vk*MYC model, analyzed the data and contributed to writing the paper. CC contributed to the experimental design and to writing the paper. AC designed the experimental work, performed research and wrote the manuscript.

Author information

Affiliations

  1. Division of Genetics and Cell Biology, IRCCS Ospedale San Raffaele,Milan, Italy

    • J Bordini
    • , S Galvan
    • , C Camaschella
    •  & A Campanella
  2. Vita-Salute San Raffaele University, Milan, Italy

    • J Bordini
    •  & C Camaschella
  3. Pathology and Myeloma Units, IRCCS Ospedale San Raffaele, Milan, Italy

    • M Ponzoni
  4. Division of Molecular Oncology, IRCCS Ospedale San Raffaele, Milan, Italy

    • M T S Bertilaccio
  5. Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    • M T S Bertilaccio
  6. Comprehensive Cancer Center, Mayo Clinic, Scottsdale, AZ, USA

    • M Chesi
    •  & P L Bergsagel
  7. Fondazione Centro San Raffaele, Milan, Italy

    • A Campanella

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Competing interests

The authors declare no conflict of interest.

Corresponding author

Correspondence to A Campanella.

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DOI

https://doi.org/10.1038/leu.2016.346

Supplementary Information accompanies this paper on the Leukemia website (http://www.nature.com/leu)