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Identification of MYC mutations in acute myeloid leukemias with NUP98NSD1 translocations


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This work was supported by the Government of Canada through Genome Canada and the Ministère de l’économie, de l’innovation et des exportations du Québec through Génome Québec, with supplementary funds from AmorChem. We thank Muriel Draoui for project coordination and Sophie Corneau for sample coordination, as well as Marianne Arteau and Raphaëlle Lambert at the IRIC genomics platform for RNA sequencing. The dedicated work of BCLQ staff, namely, Giovanni d’Angelo, Claude Rondeau and Sylvie Lavallée, is also acknowledged. GS and JH are recipients of research chairs from the Canada Research Chair program and Industrielle-Alliance (Université de Montréal). BCLQ is supported by grants from the Cancer Research Network of the Fonds de recherche du Québec–Santé. RNA-Seq read mapping and transcript quantification were performed on the supercomputer Briaree from the Université de Montréal, managed by Calcul Québec and Compute Canada. The operation of this supercomputer is funded by the Canada Foundation for Innovation (CFI), NanoQuébec, RMGA and the Fonds de recherche du Québec – Nature et technologies (FRQ-NT). V-PL is supported by a postdoctoral fellowship jointly supported by Hôpital Maisonneuve-Rosemont’s Foundation and by Cole Foundation. Accession codes: GSE49642, GSE52656, GSE62190, GSE66917, GSE67039.

Author contributions

V-PL analyzed the exomes and transcriptomes of all samples, generated the corresponding figures, tables and Supplementary Material, and co-wrote the paper. GS contributed to project conception and coordination, and co-wrote the paper. JH contributed to project conception, analyzed the cytogenetic and FISH studies, provided all the AML samples and edited the manuscript. PG processed the raw NGS data. GB co-developed the analytical pipeline. SL was responsible for supervision of the bioinformatics team and of statistical analyses. IB performed data validation. SG performed immunoblot experiment.

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Correspondence to J Hébert or G Sauvageau.

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The authors declare no conflict of interest.

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Lavallée, VP., Lemieux, S., Boucher, G. et al. Identification of MYC mutations in acute myeloid leukemias with NUP98NSD1 translocations. Leukemia 30, 1621–1624 (2016).

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