Adult acute myeloid leukemia with trisomy 11 as the sole abnormality is characterized by the presence of five distinct gene mutations: MLL-PTD, DNMT3A, U2AF1, FLT3-ITD and IDH2

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Acknowledgements

The authors are grateful to the patients who consented to participate in these clinical trials and the families who supported them; to Donna Bucci and the CALGB/Alliance Leukemia Tissue Bank at The Ohio State University Comprehensive Cancer Center, Columbus, OH, for sample processing and storage services; and to Lisa J. Sterling and Chris Finks for data management. This work was supported in part by the National Cancer Institute (grants CA180821 and CA180882 (to the Alliance for Clinical Trials in Oncology), CA140158, CA180861, CA196171, CA180850, CA16058 and CA77658), the Coleman Leukemia Research Foundation, the Warren D. Brown Foundation, the Pelotonia Fellowship Program (A-KE), and by an allocation of computing resources from The Ohio Supercomputer Center.

Author contributions

A-KE, JK, KM, JCB, and CDB contributed to the study design; A-KE, JK, KM, AdlC and CDB contributed to the data interpretation, A-KE, JK, KM and CDB wrote the manuscript; A-KE and SO performed laboratory-based research; JSB and KK performed the data processing; JK and DN performed statistical analysis; AJC, RMS, KM and CDB were involved directly or indirectly in the care of patients and/or sample procurement. All authors read and agreed on the final version of the manuscript.

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Correspondence to A-K Eisfeld or C D Bloomfield.

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The authors declare no conflict of interest.

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Supplementary Information accompanies this paper on the Leukemia website

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Eisfeld, A., Kohlschmidt, J., Mrózek, K. et al. Adult acute myeloid leukemia with trisomy 11 as the sole abnormality is characterized by the presence of five distinct gene mutations: MLL-PTD, DNMT3A, U2AF1, FLT3-ITD and IDH2. Leukemia 30, 2254–2258 (2016) doi:10.1038/leu.2016.196

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