Access optionsAccess options
Subscribe to Journal
Get full journal access for 1 year
only $102.00 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
All prices are NET prices.
Yang L, Rau R, Goodell MA . DNMT3A in haematological malignancies. Nat Rev Cancer 2015; 15: 152–165.
Ley TJ, Ding L, Walter MJ, McLellan MD, Lamprecht T, Larson DE et al. DNMT3A mutations in acute myeloid leukemia. N Engl J Med 2010; 363: 2424–2433.
Yan XJ, Xu J, Gu ZH, Pan CM, Lu G, Shen Y et al. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet 2011; 43: 309–315.
Xu J, Wang YY, Dai YJ, Zhang W, Zhang WN, Xiong SM et al. DNMT3A Arg882 mutation drives chronic myelomonocytic leukemia through disturbing gene expression/DNA methylation in hematopoietic cells. Proc Natl Acad Sci USA 2014; 111: 2620–2625.
Shen Y, Zhu YM, Fan X, Shi JY, Wang QR, Yan XJ et al. Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia. Blood 2011; 118: 5593–5603.
Muntean AG, Hess JL . The pathogenesis of mixed-lineage leukemia. Annu Rev Pathol 2012; 7: 283–301.
Hanson RD, Hess JL, Yu BD, Ernst P, van Lohuizen M, Berns A et al. Mammalian trithorax and polycomb-group homologues are antagonistic regulators of homeotic development. Proc Natl Acad Sci USA 1999; 96: 14372–14377.
Xia ZB, Anderson M, Diaz MO, Zeleznik-Le NJ . MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein. Proc Natl Acad Sci USA 2003; 100: 8342–8347.
Negishi M, Saraya A, Miyagi S, Nagao K, Inagaki Y, Nishikawa M et al. Bmi1 cooperates with Dnmt1-associated protein 1 in gene silencing. Biochem Biophys Res Commun 2007; 353: 992–998.
So CW, Lin M, Ayton PM, Chen EH, Cleary ML . Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias. Cancer Cell 2003; 4: 99–110.
Valtieri M, Tweardy DJ, Caracciolo D, Johnson K, Mavilio F, Altmann S et al. Cytokine-dependent granulocytic differentiation. Regulation of proliferative and differentiative responses in a murine progenitor cell line. J Immunol 1987; 138: 3829–3835.
Cao R, Tsukada Y, Zhang Y . Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol Cell 2005; 20: 845–854.
Smith LL, Yeung J, Zeisig BB, Popov N, Huijbers I, Barnes J et al. Functional crosstalk between Bmi1 and MLL/Hoxa9 axis in establishment of normal hematopoietic and leukemic stem cells. Cell Stem Cell 2011; 8: 649–662.
Yuan J, Takeuchi M, Negishi M, Oguro H, Ichikawa H, Iwama A . Bmi1 is essential for leukemic reprogramming of myeloid progenitor cells. Leukemia 2011; 25: 1335–1343.
Liu H, Westergard TD, Cashen A, Piwnica-Worms DR, Kunkle L, Vij R et al. Proteasome inhibitors evoke latent tumor suppression programs in pro-B MLL leukemias through MLL-AF4. Cancer Cell 2014; 25: 530–542.
Special thanks are due to Dr Yuet W Kan (UCSF) for his kind support to this project. We also thank Dr Scott C Kogan (UCSF) for providing 32D cells. This work was supported by the Chinese National Key Basic Research Project (973: 2013CB966800) to S-JC and HL, the National Natural Science Foundation of China (81370651 and 81570119) to HL, the Thousand Young Talents program of China to HL, the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning (2012-70) to HL, the Shu Guang project supported by Shanghai Municipal Education Commission and Shanghai Education Development Foundation (14SG15) to HL and the American Society of Hematology Scholar Award to HL.
The authors declare no conflict of interest.
Supplementary Information accompanies this paper on the Leukemia website