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Analysis of mutational signatures in exomes from B-cell lymphoma cell lines suggest APOBEC3 family members to be involved in the pathogenesis of primary effusion lymphoma

Leukemia volume 29, pages 16121615 (2015) | Download Citation

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References

  1. 1.

    International Agency for Research on Cancer, World Health Organization WHO classification of tumours of haematopoietic and lymphoid tissues. International Agency for Research on Cancer: Lyon, France, 2008.

  2. 2.

    . Kaposi’s sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8 (HHV-8) as a tumour virus. Herpes 2003; 10: 72–77.

  3. 3.

    , , , , , . Primary effusion lymphomas exhibit complex and recurrent cytogenetic abnormalities. Br J Haematol 2002; 116: 113–121.

  4. 4.

    , , , , , et al. Primary body cavity-based AIDS-related lymphomas. Am J Clin Pathol 1996; 105: 221–229.

  5. 5.

    , . The role of cytidine deaminases on innate immune responses against human viral infections. BioMed Res Int 2013; 2013: 683095.

  6. 6.

    , , , , , et al. Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivo. J Virol 2011; 85: 7594–7602.

  7. 7.

    , , , , , et al. APOBEC3B is an enzymatic source of mutation in breast cancer. Nature 2013; 494: 366–370.

  8. 8.

    , , , , , et al. Signatures of mutational processes in human cancer. Nature 2013; 500: 415–421.

  9. 9.

    , , , . BAX frameshift mutations in cell lines derived from human haemopoietic malignancies are associated with resistance to apoptosis and microsatellite instability. Oncogene 1998; 16: 1803–1812.

  10. 10.

    , , , , , . Distinct subsets of primary effusion lymphoma can be identified based on their cellular gene expression profile and viral association. J Virol 2005; 79: 1244–1251.

  11. 11.

    , , , , , et al. Gene expression profile analysis of AIDS-related primary effusion lymphoma (PEL) suggests a plasmablastic derivation and identifies PEL-specific transcripts. Blood 2003; 101: 4115–4121.

  12. 12.

    , , , , , . Reverse engineering of regulatory networks in human B cells. Nat Genet 2005; 37: 382–390.

  13. 13.

    , , , , , et al. Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus. Nat Genet 2004; 36: 683–685.

  14. 14.

    , , , . Functional genomic relationships in HIV-1 disease revealed by gene-expression profiling of primary human peripheral blood mononuclear cells. J Infect Dis 2005; 191: 2064–2074.

  15. 15.

    , , , , , et al. Microarray analysis of lymphatic tissue reveals stage-specific, gene expression signatures in HIV-1 infection. J Immunol 2009; 183: 1975–1982.

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Acknowledgements

This study was supported by the German Ministry of Education and Science (BMBF) through the International Cancer Genome Consortium (ICGC) MMML-Seq Project (01KU1002A to 01KU1002J) and the e:Bio ‘MMML-MYC-SYS’ project (BMBF FKZ 0316166). RW is supported by a Christoph-Schubert-Award of the KinderKrebsInitiative Buchholz/Holm-Seppensen. Research performed at Los Alamos National Laboratory was carried out under the auspices of the National Nuclear Security Administration of the US Department of Energy.

Author information

Affiliations

  1. Institute of Human Genetics, University Hospital Schleswig-Holstein, Christian-Albrechts-University Kiel, Campus Kiel, Kiel, Germany

    • R Wagener
    • , A Haake
    • , J Richter
    •  & R Siebert
  2. Cancer Genome Project, Wellcome Trust Cancer Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK

    • L B Alexandrov
    • , G R Bignell
    •  & U McDermott
  3. Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM, USA

    • L B Alexandrov
  4. Institute for Neuropathology, University Hospital of Cologne, Cologne, Germany

    • M Montesinos-Rongen
  5. Division of Theoretical Bioinformatics, Deutsches Krebsforschungszentrum Heidelberg (DKFZ), Heidelberg, Germany

    • M Schlesner
  6. Leibniz-Institute DSMZ- German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany

    • H G Drexler

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The authors declare no conflict of interest.

Corresponding author

Correspondence to R Siebert.

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DOI

https://doi.org/10.1038/leu.2015.22

Supplementary Information accompanies this paper on the Leukemia website (http://www.nature.com/leu)

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