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Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia

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We thank the patients who participated in the study. We acknowledge personnel of the High Throughput Biomedicine Unit and Minna Suvela, Pekka Ellonen, Aino Palva, Pirkko Mattila and Henrikki Almusa from Institute for Molecular Medicine Finland (FIMM) Technology Centre, University of Helsinki for their expert technical assistance. The Finnish Cancer Societies, Blood Disease Foundation, Finnish Association of Hematology, Orion-Farmos Research Foundation, Academy of Finland, Finnish Funding Agency for Technology and Innovation, and European Regional Development Fund supported this work.

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Correspondence to C A Heckman.

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The authors declare no conflict of interest.

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Author contributions

MK and HK designed the study, analyzed the data and wrote the manuscript; MK collected most of the sample material; HK performed most of the experiments; SE, HE and JMLM performed sequencing data analysis; TP and MMM performed drug sensitivity testing and corresponding analysis; EIA, SL, HR, MMM and AP performed the experiments and participated in the data analysis; TB, ØB, THB, BTG, OL, TL and KV provided the patient specimens and clinical data; and OK, SM, KP and CAH conceived the study, supervised the work and wrote the manuscript. All authors contributed to and approved the final manuscript.

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Kontro, M., Kuusanmäki, H., Eldfors, S. et al. Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia. Leukemia 28, 1738–1742 (2014).

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