Figure 6 | Leukemia

Figure 6

From: Calreticulin mutation-specific immunostaining in myeloproliferative neoplasms: pathogenetic insight and diagnostic value

Figure 6

Diagnostic algorithms for CALR-mutated myeloproliferative neoplasms. In scenario 1, a standard ‘genotype-exclusive’ diagnostic algorithm is presented, whereas in the flow chart shown in scenario 2 immunostaining with anti-mutated calreticulin is used at the time of bone marrow biopsy to rule out a CALR-mutated MPN before genotyping for JAK2V617F and MPL mutations. See Discussion for details.

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