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Leukemic evolution of donor-derived cells harboring IDH2 and DNMT3A mutations after allogeneic stem cell transplantation

Leukemia volume 28, pages 426–428 (2014)Cite this article

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Although allogeneic stem cell transplantation is effective for the treatment of leukemia with poor prognosis, some such treated individuals experience disease relapse at various times after transplantation. Chimerism analysis of the relapsed disease has revealed infrequent cases in which the malignant cells originate from the donor and not from the initial leukemic clones.1, 2 Such donor cell leukemia (DCL) is often refractory to further treatment, with a mean overall survival for the affected patients of only 32.8 months.2

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Acknowledgements

This study was supported in part by a Grant-in-Aid from the Project for Development of Innovative Research on Cancer Therapeutics (P-Direct) from the Ministry of Education, Culture, Sports, Science and Technology of Japan and by grants for Third-Term Comprehensive Control Research for Cancer and for Research on Human Genome Tailor-made from the Ministry of Health, Labor and Welfare of Japan.

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Authors and Affiliations

  1. Department of Cellular Signaling, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

    T Yasuda, T Ueno, K Fukumura, A Yamato, M Ando, H Yamaguchi, M Soda & H Mano

  2. Department of Hematology and Oncology, Graduate School of Medicine, Nagoya University, Aichi, Japan

    T Yasuda, M Murata, H Kiyoi & T Naoe

  3. Department of Medical Genomics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

    M Kawazu, E Sai & Y Yamashita

  4. National Hospital Organization Nagoya Medical Center, Aichi, Japan

    T Naoe

  5. CREST, Japan Science and Technology Agency, Saitama, Japan

    H Mano

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  1. T Yasuda
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Correspondence to H Mano.

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Yasuda, T., Ueno, T., Fukumura, K. et al. Leukemic evolution of donor-derived cells harboring IDH2 and DNMT3A mutations after allogeneic stem cell transplantation. Leukemia 28, 426–428 (2014). https://doi.org/10.1038/leu.2013.278

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