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Leukemic evolution of donor-derived cells harboring IDH2 and DNMT3A mutations after allogeneic stem cell transplantation

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  1. Fialkow PJ, Thomas ED, Bryant JI, Neiman PE . Leukaemic transformation of engrafted human marrow cells in vivo. Lancet 1971; 1: 251–255.

    CAS  Article  Google Scholar 

  2. Wiseman DH . Donor cell leukemia: a review. Biol Blood Marrow Transplant 2011; 17: 771–789.

    Article  Google Scholar 

  3. Murata M, Ishikawa Y, Ohashi H, Terakura S, Ozeki K, Kiyoi H et al. Donor cell leukemia after allogeneic peripheral blood stem cell transplantation: a case report and literature review. Int J Hematol 2008; 88: 111–115.

    Article  Google Scholar 

  4. Kubonishi I, Miyoshi I . Establishment of a Ph1 chromosome-positive cell line from chronic myelogenous leukemia in blast crisis. Int J Cell Cloning 1983; 1: 105–117.

    CAS  Article  Google Scholar 

  5. Prior IA, Lewis PD, Mattos C . A comprehensive survey of Ras mutations in cancer. Cancer Res 2012; 72: 2457–2467.

    CAS  Article  Google Scholar 

  6. Birch JM, Alston RD, McNally RJ, Evans DG, Kelsey AM, Harris M et al. Relative frequency and morphology of cancers in carriers of germline TP53 mutations. Oncogene 2001; 20: 4621–4628.

    CAS  Article  Google Scholar 

  7. Sala-Torra O, Hanna C, Loken MR, Flowers ME, Maris M, Ladne PA et al. Evidence of donor-derived hematologic malignancies after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2006; 12: 511–517.

    Article  Google Scholar 

  8. Busque L, Patel JP, Figueroa ME, Vasanthakumar A, Provost S, Hamilou Z et al. Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis. Nat Genet 2012; 44: 1179–1181.

    CAS  Article  Google Scholar 

  9. Jan M, Snyder TM, Corces-Zimmerman MR, Vyas P, Weissman IL, Quake SR et al. Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia. Sci Transl Med 2012; 4: 149ra118.

    Article  Google Scholar 

  10. Wakita S, Yamaguchi H, Omori I, Terada K, Ueda T, Manabe E et al. Mutations of the epigenetics-modifying gene (DNMT3a, TET2, IDH1/2) at diagnosis may induce FLT3-ITD at relapse in de novo acute myeloid leukemia. Leukemia 2013; 27: 1044–1052.

    CAS  Article  Google Scholar 

  11. Network TCGAR. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med 2013; 368: 2059–2074.

    Article  Google Scholar 

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This study was supported in part by a Grant-in-Aid from the Project for Development of Innovative Research on Cancer Therapeutics (P-Direct) from the Ministry of Education, Culture, Sports, Science and Technology of Japan and by grants for Third-Term Comprehensive Control Research for Cancer and for Research on Human Genome Tailor-made from the Ministry of Health, Labor and Welfare of Japan.

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Correspondence to H Mano.

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Yasuda, T., Ueno, T., Fukumura, K. et al. Leukemic evolution of donor-derived cells harboring IDH2 and DNMT3A mutations after allogeneic stem cell transplantation. Leukemia 28, 426–428 (2014).

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