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Overexpression of SNORD114-3 marks acute promyelocytic leukemia

Leukemia volume 28, pages 233–236 (2014)Cite this article

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A global downregulation of small nucleolar RNAs (snoRNA) was reported in acute lymphoblastic (ALL) and acute myeloid leukemias (AML) by Valleron et al.1 The authors also identified a specific snoRNA signature in acute promyelocytic leukemia (APL) with overexpression of snoRNA clusters SNORD112-114. Recently, Cohen et al.2 reported a marked overexpression of SNORD113-3, SNORD113-4, SNORD114-2 and SNORD114-3 in three additional cases of APL.

We have compiled a hematological gene expression data set of neoplastic and non-neoplastic samples hybridized to Affymetrix HG-U133 Plus 2.0 GeneChips, all downloaded from the GEO microarray repository. The data were collected as described earlier by Heinäniemi et al.3 Of all the genes on the microarray, 15 were identified as snoRNAs (Table 1). They represent various types of snoRNAs, including H/ACA and CD box types, small Cajal body-specific RNAs (scaRNA), intergenic and intronic snoRNAs, and even one snoRNA without any known target RNA (so-called ‘orphan’ snoRNA).

Table 1 Characteristics of 15 selected snoRNAs
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Figure 1

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Authors and Affiliations

  1. Institute of Biomedical Technology, University of Tampere, Tampere, Finland

    T Liuksiala, K Granberg, M Annala & M Nykter

  2. Department of Signal Processing, Tampere University of Technology, Tampere, Finland

    T Liuksiala, K Granberg & M Annala

  3. Tampere Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland

    K J Teittinen, M Mäki & O Lohi

  4. A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland

    M Heinäniemi

  5. BioMediTech, Tampere, Finland

    M Nykter

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  1. T Liuksiala
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Correspondence to O Lohi.

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Liuksiala, T., Teittinen, K., Granberg, K. et al. Overexpression of SNORD114-3 marks acute promyelocytic leukemia. Leukemia 28, 233–236 (2014). https://doi.org/10.1038/leu.2013.250

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