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Recurrent involvement of ring-type zinc finger genes in complex molecular rearrangements in childhood acute myelogeneous leukemia with translocation t(10;11)(p12;q23)

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References

  1. Chaplin T, Ayton P, Bernard OA, Saha V, Della Valle V, Hillion J et al. A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia. Blood 1995; 85: 1435–1441.

    CAS  PubMed  Google Scholar 

  2. Chaplin T, Bernard O, Beverloo HB, Saha V, Hagemeijer A, Berger R et al. The t(10;11) translocation in acute myeloid leukemia (M5) consistently fuses the leucine zipper motif of AF10 onto the HRX gene. Blood 1995; 86: 2073–2076.

    CAS  PubMed  Google Scholar 

  3. Meyer C, Kowarz E, Hofmann J, Renneville A, Zuna J, Trka J et al. New insights to the MLL recombinome of acute leukemias. Leukemia 2009; 23: 1490–1499.

    Article  CAS  PubMed  Google Scholar 

  4. Morerio C, Rapella A, Tassano E, Rosanda C, Panarello C . MLL-MLLT10 fusion gene in pediatric acute megakaryoblastic leukemia. Leuk Res 2005; 29: 1223–1226.

    Article  CAS  PubMed  Google Scholar 

  5. Beverloo HB, Le Coniat M, Wijsman J, Lillington DM, Bernard O, de Klein A et al. Breakpoint heterogeneity in t(10;11) translocation in AML-M4/M5 resulting in fusion of AF10 and MLL is resolved by fluorescent in situ hybridization analysis. Cancer Res 1995; 55: 4220–4224.

    CAS  PubMed  Google Scholar 

  6. DiMartino JF, Ayton PM, Chen EH, Naftzger CC, Young BD, Cleary ML . The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10. Blood 2002; 99: 3780–3785.

    Article  CAS  PubMed  Google Scholar 

  7. Van Limbergen H, Poppe B, Janssens A, De Bock R, De Paepe A, Noens L et al. Molecular cytogenetic analysis of 10;11 rearrangements in acute myeloid leukemia. Leukemia 2002; 16: 344–351.

    Article  CAS  PubMed  Google Scholar 

  8. Chen J, Feng W, Jiang J, Deng Y, Huen MS . Ring finger protein RNF169 antagonises the ubiquitin-dependent signaling cascade at sites of dna damage. J Biol Chem 2012; 287: 27715–27722.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Poulsen M, Lukas C, Lukas J, Bekker-Jensen S, Mailand N . Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks. J Cell Biol 2012; 197: 189–199.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

We wish to thank the colleagues in the pediatric oncology centers and all parents who gave their consent to use the biological material from the minors. AB was supported by grants from the BMBF. JB was funded by a grant of the Parents’ Leukemia Foundation Gießen.

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Correspondence to S Ghosh.

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Supplementary Information accompanies the paper on the Leukemia website

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Ghosh, S., Bartenhagen, C., Okpanyi, V. et al. Recurrent involvement of ring-type zinc finger genes in complex molecular rearrangements in childhood acute myelogeneous leukemia with translocation t(10;11)(p12;q23). Leukemia 27, 1745–1748 (2013). https://doi.org/10.1038/leu.2013.1

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