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MiR-125 in normal and malignant hematopoiesis

Leukemia volume 26, pages 2011–2018 (2012)Cite this article

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Abstract

MiR-125 is a highly conserved microRNA throughout many different species from nematode to humans. In humans, there are three homologs (hsa-miR-125b-1, hsa-miR-125b-2 and hsa-miR-125a). Here we review a recent research on the role of miR-125 in normal and malignant hematopoietic cells. Its high expression in hematopoietic stem cells (HSCs) enhances self-renewal and survival. Its expression in specific subtypes of myeloid and lymphoid leukemias provides resistance to apoptosis and blocks further differentiation. A direct oncogenic role in the hematopoietic system has recently been demonstrated by several mouse models. Targets of miR-125b include key proteins regulating apoptosis, innate immunity, inflammation and hematopoietic differentiation.

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Acknowledgements

We thank Y Kirschenbaum for reading and correcting the manuscript. This work was supported by the German Israeli Foundation (SI and AB), ISF-Legacy program (SI), Children with Leukemia UK (SI), Waxman Cancer Foundation NY (SI), the National Institutes of Health (SI), Wolfson foundation (SI), i-CORE (SI), and the WLBH Foundation (SI).

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Authors and Affiliations

  1. Department of Pediatric Hemato-Oncology, Functional Genomics and Childhood Leukemia Research, Cancer Research Center, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel

    L Shaham, N Gefen & S Izraeli

  2. The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel

    L Shaham

  3. Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany

    V Binder & A Borkhardt

  4. Stem Cell Program and Division of Hematology/Oncology, Children's Hospital, Harvard Stem Cell Institute, Harvard Medical School,

    V Binder

  5. Boston, MA, USA

    V Binder

  6. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    N Gefen & S Izraeli

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  1. L Shaham
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Correspondence to S Izraeli.

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The study is partial fulfillment of the requirements for completing a PhD degree (Lital Shaham) for Bar-Ilan University, Ramat Gan, Israel.

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Shaham, L., Binder, V., Gefen, N. et al. MiR-125 in normal and malignant hematopoiesis. Leukemia 26, 2011–2018 (2012). https://doi.org/10.1038/leu.2012.90

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Keywords

  • microRNA
  • hematopoiesis
  • hematological malignancies
  • acute myeloid leukemia
  • acute lymphoblastic leukemia

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