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Comparison of outcomes between autologous and allogeneic hematopoietic stem cell transplantation for peripheral T-cell lymphomas with central review of pathology

Leukemia volume 27, pages 1394–1397 (2013)Cite this article

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High-dose therapy with autologous hematopoietic stem cell transplantation (auto-SCT) for peripheral T-cell lymphomas (PTCLs) has been evaluated as a consolidation of the first remission and salvage therapy for relapse.1, 2, 3, 4, 5, 6, 7 However, no randomized trial comparing conventional chemotherapy followed by auto-SCT and conventional chemotherapy alone has been performed. Although data for allogeneic (allo-) SCT in selected patients with PTCLs have been reported to be promising,8, 9, 10, 11, 12, 13 no large-scale prospective study has been performed thus far. To clarify the roles of auto- and allo-SCT in the treatment of PTCLs, the Japan Study Group for Cell Therapy and Transplantation conducted a retrospective study of SCT for patients with PTCLs with central review of pathology. The study protocol was approved by the institutional review board at each center.

We collected the clinical data of 336 patients with PTCLs diagnosed at 52 Japanese and 8 Korean centers between September 1991 and December 2008, obtained the pathological samples of 307 patients, and conducted central review of pathology on the basis of the World Health Organization classification (Supplementary Figure S1).14 Patients with adult T-cell leukemia/lymphoma (ATLL) and natural killer (NK) cell tumors, aged less than 15 years at SCT and who received a planned tandem SCT were excluded. Following the review, we analyzed the data of 231 patients (135 auto-SCTs and 96 allo-SCTs).

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Acknowledgements

We would like to thank pathologists Dr Hironori Haga and Dr Yoon Kyung Jeon for attending the consensus conference. We also thank the JSCT Office for outstanding data management. Further, we thank Dr Yoichi Takaue, Dr Kensei Tobinai, Dr Takashi Watanabe and Dr Shigeo Fuji for the discussions. This work was supported by a grant from the Regional Medicine Research Foundation (Utsunomiya, Japan).

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Authors and Affiliations

  1. Department of Hematology and Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan

    S-W Kim & T Fukuda

  2. Department of Hematology, Seoul National University, Seoul, Korea

    S-S Yoon

  3. Department of HSCT Data Management, Nagoya University, Nagoya, Japan

    R Suzuki

  4. Department of Pathology, Hokkaido University, Sapporo, Japan

    Y Matsuno

  5. Department of Internal Medicine, Inha University, Incheon, Korea

    H G Yi & C S Kim

  6. Department of Hematology, Toyama Prefectural Central Hospital, Toyama, Japan

    T Yoshida

  7. Department of Hematology, Hokkaido University, Sapporo, Japan

    M Imamura

  8. Department of Hematology, Toranomon Hospital, Tokyo, Japan

    A Wake

  9. Department of Hematology and Rheumatology, Nihon University, Tokyo, Japan

    K Miura

  10. Department of Hematology, Osaka City University, Osaka, Japan

    M Hino

  11. Department of Hematology and Oncology, Kyoto University, Kyoto, Japan

    T Ishikawa

  12. Department of Hematology, Yonsei University Severance Hospital, Seoul, Korea

    J S Kim

  13. Department of Hematology, Okayama University, Okayama, Japan

    Y Maeda

  14. Department of Hematology, Chonnam National University Hwasun Hospital, Hwasun, Korea

    J-J Lee

  15. Division of Hematology/Oncology, Department of Internal Medicine, Korea Cancer Center Hospital, Seoul, Korea

    H J Kang

  16. Department of Hematology, Kosin University Gospel Hospital, Busan, Korea

    H S Lee

  17. Department of Hematology, University of Ulsan, Asan Medical Hospital, Seoul, Korea

    J-H Lee

  18. Division of Hematology, NTT Medical Center Tokyo, Tokyo, Japan

    K Izutsu

  19. Department of Pathology, Seoul National University, Seoul, Korea

    C W Kim

  20. Department of Pathology, Okayama University, Okayama, Japan

    T Yoshino

  21. Department of Pathology, Kurume University, Kurume, Japan

    K Ohshima

  22. Department of Pathology and Laboratory Medicine, Nagoya University, Nagoya, Japan

    S Nakamura

  23. Department of Hematology and Oncology, Kyushu University, Fukuoka, Japan

    K Nagafuji

  24. Department of Hematology, Shimane University, Izumo, Japan

    J Suzumiya

  25. National Hospital Organization, Oomuta Hospital, Oomuta, Japan

    M Harada

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  1. S-W Kim
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Corresponding author

Correspondence to S-W Kim.

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Supplementary Information accompanies the paper on the Leukemia website

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Kim, SW., Yoon, SS., Suzuki, R. et al. Comparison of outcomes between autologous and allogeneic hematopoietic stem cell transplantation for peripheral T-cell lymphomas with central review of pathology. Leukemia 27, 1394–1397 (2013). https://doi.org/10.1038/leu.2012.321

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