Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter to the Editor
  • Published:

Are ARID5B and IKZF1 polymorphisms also associated with childhood acute myeloblastic leukemia: the ESCALE study (SFCE)?

Leukemia volume 27, pages 746–748 (2013)Cite this article

Subjects

Of the average 470 new cases of acute leukemia (AL) registered annually in France among children aged <15 years,1 ∼90 are cases of acute myeloblastic leukemia (AML). Down’s syndrome and other inheritable predisposing diseases explain only a small proportion of AML. Most childhood AML occurs before the age of 2 years, and researches have mainly focused on antenatal or early childhood exposures.2 Advances in genetic technologies have enabled genome-wide association studies (GWAS) to be undertaken with the aim of identifying common single-nucleotide polymorphism variant alleles associated with small increases in AL risk. GWAS on acute lymphoblastic leukemia (ALL) have previously identified SNPs in ARID5B (rs7073837, rs10740055, rs7089424, rs10821936 and rs10994982)3, 4, 5, 6 and IKZF1 (rs6964823, rs4132601, rs6944602 and rs11978267).3, 4, 5, 6 In the present paper, the associations between childhood AML and the polymorphisms previously identified for ALL in ARID5B and IKZF1 were investigated in a candidate gene approach, using the data from the ESCALE case–control study.

The ESCALE study has been previously described in detail.7, 8 Briefly, the cases were children <15 years old diagnosed with AL, lymphoma, central nervous system tumor or neuroblastoma in 2003–2004 and identified through the National Registry of Childhood Hematopoietic Malignancies. The study included 101 AML cases, 92% of the 110 eligible cases. A blood sample was obtained from 89 cases (88% of the included cases), 66 of whom were successfully genotyped. The ESCALE controls were randomly selected contemporaneously with the cases from French households with a landline telephone. Of the 2360 eligible controls identified, 1681 controls (71%) were included, 810 of whom provided buccal swab brushes, and 570 were successfully genotyped for candidate SNPs.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Lacour B, Guyot-Goubin A, Guissou S, Bellec S, Desandes E, Clavel J . Incidence of childhood cancer in France: National Children Cancer Registries, 2000–2004. Eur J Cancer Prev 2010; 19: 173–181.

    Article  Google Scholar 

  2. Eden T . Aetiology of childhood leukaemia. Cancer Treat Rev 2010; 36: 286–297.

    Article  CAS  Google Scholar 

  3. Papaemmanuil E, Hosking FJ, Vijayakrishnan J, Price A, Olver B, Sheridan E et al. Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia. Nat Genet 2009; 41: 1006–U1073.

    Article  CAS  Google Scholar 

  4. Trevino LR, Yang WJ, French D, Hunger SP, Carroll WL, Devidas M et al. Germline genomic variants associated with childhood acute lymphoblastic leukemia. Nat Genet 2009; 41: 1001–U1067.

    Article  CAS  Google Scholar 

  5. Ellinghaus E, Stanulla M, Richter G, Ellinghaus D, Kronnie GT, Cario G et al. Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. Leukemia 2012; 26: 902–909.

    Article  CAS  Google Scholar 

  6. Orsi L, Rudant J, Bonaventure A, Goujon-Bellec S, Corda E, Evans T et al. Genetic polymorphisms and childhood acute lymphoblastic leukemia: GWAS of the ESCALE study (SFCE). Leukemia 2012; e-pub ahead of print 29 June 2012; doi:10.1038/leu.2012.148.

    Article  CAS  Google Scholar 

  7. Rudant J, Menegaux F, Leverger G, Baruchel A, Nelken B, Bertrand Y et al. Family history of cancer in children with acute leukemia, Hodgkin’s lymphoma or non-Hodgkin’s lymphoma: the ESCALE study (SFCE). Int J Cancer 2007; 121: 119–126.

    Article  CAS  Google Scholar 

  8. Rudant J, Orsi L, Menegaux F, Petit A, Baruchel A, Bertrand Y et al. Childhood acute leukemia, early common infections, and allergy: the ESCALE study. Am J Epidemiol 2010; 172: 1015–1027.

    Article  Google Scholar 

  9. Brosselin P, Rudant J, Orsi L, Leverger G, Baruchel A, Bertrand Y et al. Acute childhood leukaemia and residence next to petrol stations and automotive repair garages: the ESCALE study (SFCE). Occup Environ Med 2009; 66: 598–606.

    Article  CAS  Google Scholar 

  10. Rudant J, Menegaux F, Leverger G, Baruchel A, Nelken B, Bertrand Y et al. Household exposure to pesticides and risk of childhood hematopoietic malignancies: the ESCALE study (SFCE). Environ Health Perspect 2007; 115: 1787–1793.

    Article  Google Scholar 

  11. Mullighan CG, Su X, Zhang J, Radtke I, Phillips LAA, Miller CB et al. Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med 2009; 360: 470–480.

    Article  CAS  Google Scholar 

  12. Ross J, Linabery A, Blommer C, Langer E, Spector L, Hilden J et al. Genetic variants modify susceptibility to leukemia in infants: A Children’s Oncology Group report. Pediatr Blood Cancer 2012; e-pub ahead of print 15 March 2012; doi:10.1002/pbc.24131.

    Article  Google Scholar 

Download references

Acknowledgements

We are grateful to Claire Mulot, who was in charge of the biological collection at the Biological Resource Center of Saints-Pères, INSERM U775; the CEPH and the Centre National de Génotypage, who genotyped the cases; and IntegraGen, who genotyped the controls. We thank Florence Demenais and the UMR-946 unit (Inserm-Université Paris Diderot) and Fondation Jean Dausset-CEPH for their support. We express our gratitude to: Marie-Hélène Da Silva, Christophe Steffen and Florence Menegaux (INSERM U1018, Environmental Epidemiology of Cancer), who contributed to the recruitment of the cases; Aurélie Guyot-Goubin and the staff of the French National Registry of Childhood Blood Malignancies, who contributed to case detection and verification; and Sabine Mélèze and Marie-Anne Noel (Institut CSA), who coordinated the selection of the controls. We also thank all of the Société Française de lutte contre les Cancers de l’Enfant et de l’Adolescent (SFCE) principal investigators: André Baruchel (Hôpital Saint-Louis/Hôpital Robert Debré, Paris), Claire Berger (Centre Hospitalier Universitaire, Saint-Etienne), Christophe Bergeron (Centre Léon Bérard, Lyon), Jean-Louis Bernard (Hôpital La Timone, Marseille), Yves Bertrand (Hôpital Debrousse, Lyon), Pierre Bordigoni (Centre Hospitalier Universitaire, Nancy), Patrick Boutard (Centre Hospitalier Régional Universitaire, Caen), Gérard Couillault (Hôpital d’Enfants, Dijon), Christophe Piguet (Centre Hospitalier Régional Universitaire, Limoges), Anne-Sophie Defachelles (Centre Oscar Lambret, Lille), François Demeocq (Hôpital Hôtel-Dieu, Clermont-Ferrand), Alain Fischer (Hôpital des Enfants Malades, Paris), Virginie Gandemer (Centre Hospitalier Universitaire – Hôpital Sud, Rennes), Dominique Valteau-Couanet (Institut Gustave Roussy, Villejuif), Jean-Pierre Lamagnere (Centre Gatien de Clocheville, Tours), Françoise Lapierre (Centre Hospitalier Universitaire Jean Bernard, Poitiers), Guy Leverger (Hôpital Armand-Trousseau, Paris), Patrick Lutz (Hôpital de Hautepierre, Strasbourg), Geneviève Margueritte (Hôpital Arnaud de Villeneuve, Montpellier), Françoise Mechinaud (Hôpital Mère et Enfants, Nantes), Gérard Michel (Hôpital La Timone, Marseille), Frédéric Millot (Centre Hospitalier Universitaire Jean Bernard, Poitiers), Martine Münzer (American Memorial Hospital, Reims), Brigitte Nelken (Hôpital Jeanne de Flandre, Lille), Hélène Pacquement (Institut Curie, Paris), Brigitte Pautard (Centre Hospitalier Universitaire, Amiens), Yves Perel (Hôpital Pellegrin Tripode, Bordeaux), Alain Pierre-Kahn (Hôpital Enfants Malades, Paris), Emmanuel Plouvier (Centre Hospitalier Régional, Besançon), Xavier Rialland (Centre Hospitalier Universitaire, Angers), Alain Robert (Hôpital des Enfants, Toulouse), Hervé Rubie (Hôpital des Enfants, Toulouse), Nicolas Sirvent (L’Archet, Nice), Christine Soler (Fondation Lenval, Nice), and Jean-Pierre Vannier (Hôpital Charles Nicolle, Rouen). This work was supported by the grants from INSERM, the Fondation de France, the Association pour la Recherche sur le Cancer (ARC), the Agence Française de Sécurité Sanitaire des Produits de Santé (AFSSAPS), the Agence Française de Sécurité Sanitaire de l’Environnement et du Travail (AFSSET), the association Cent pour sang la vie, the Institut National du Cancer (INCa), the Agence Nationale de la Recherche (ANR), and Cancéropôle Ile de France.

Author information

Authors and Affiliations

  1. Department of Environmental Epidemiology of Cancers, INSERM, U1018, Villejuif, France

    J Rudant, L Orsi, A Bonaventure, S Goujon-Bellec, D Hémon & J Clavel

  2. Department of Environmental Epidemiology of Cancers, Paris-Sud University, UMR-S1018, Research Center in Epidemiology and Population Health, Villejuif, France

    J Rudant, L Orsi, A Bonaventure, S Goujon-Bellec, D Hémon & J Clavel

  3. French National Registr Childhood Blood Malignancies (RNHE), Villejuif, France

    J Rudant, S Goujon-Bellec & J Clavel

  4. Fondation Jean Dausset, Centre d’Etude du Polymorphisme Humain (CEPH), Paris, France

    E Corda

  5. Inserm, Univ Paris Diderot, UMR-S-946, Genetic Variation and Human Diseases Unit, Paris, France

    E Corda

  6. AP-HP, Hôpital Robert Debré, Paris, France

    A Baruchel

  7. Université Paris 7 Denis Diderot, Paris, France

    A Baruchel

  8. Institut d’Hémato-Oncologie Pédiatrique, Lyon, France

    Y Bertrand

  9. Pôle Enfant, CHRU, Lille, France

    B Nelken

  10. Université Lille Nord de France, Lille, France

    B Nelken

  11. Hôpital des Enfants, Toulouse, France

    A Robert

  12. AP-HM, Hôpital la Timone, Marseille, France

    G Michel

  13. Hôpital Arnaud de Villeneuve, Montpellier, France

    N Sirvent

  14. Hôpital d’enfants, CHU de Nancy, Vandoeuvre, France

    P Chastagner

  15. Hôpital Pellegrin Tripode, Bordeaux, France

    S Ducassou

  16. Hôpital Mère-Enfant, CHU-Nantes, Nantes, France

    X Rialland

  17. CHU d’Angers, Angers, France

    X Rialland

  18. AP-HP, Hôpital Armand Trousseau, Paris, France

    G Leverger

  19. Université Paris 6 Pierre et Marie Curie, Paris, France

    G Leverger

Authors
  1. J Rudant
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L Orsi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A Bonaventure
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S Goujon-Bellec
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. E Corda
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A Baruchel
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Y Bertrand
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. B Nelken
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. A Robert
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. G Michel
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. N Sirvent
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. P Chastagner
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. S Ducassou
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. X Rialland
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. D Hémon
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. G Leverger
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. J Clavel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to J Clavel.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Additional information

Supplementary Information accompanies the paper on the Leukemia website

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rudant, J., Orsi, L., Bonaventure, A. et al. Are ARID5B and IKZF1 polymorphisms also associated with childhood acute myeloblastic leukemia: the ESCALE study (SFCE)?. Leukemia 27, 746–748 (2013). https://doi.org/10.1038/leu.2012.244

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/leu.2012.244

This article is cited by

Search

Advanced search

Quick links