Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter to the Editor
  • Published:

A microRNA signature specific for hairy cell leukemia and associated with modulation of the MAPK–JNK pathways

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

References

  1. Tiacci E, Liso A, Piris M, Falini B . Evolving concepts in the pathogenesis of hairy-cell leukaemia. Nat Rev Cancer 2006; 6: 437–448.

    Article  CAS  Google Scholar 

  2. Basso K, Liso A, Tiacci E, Benedetti R, Pulsoni A, Foa R et al. Gene expression profiling of hairy cell leukemia reveals a phenotype related to memory B cells with altered expression of chemokine and adhesion receptors. J Exp Med 2004; 199: 59–68.

    Article  CAS  Google Scholar 

  3. Forconi F, Poretti G, Kwee I, Sozzi E, Rossi D, Rancoita PM et al. High density genome-wide DNA profiling reveals a remarkably stable profile in hairy cell leukaemia. Br J Haematol 2008; 141: 622–630.

    Article  CAS  Google Scholar 

  4. Tiacci E, Trifonov V, Schiavoni G, Holmes A, Kern W, Martelli MP et al. BRAF mutations in hairy-cell leukemia. N Engl J Med 2011; 364: 2305–2315.

    Article  CAS  Google Scholar 

  5. Tiacci E, Schiavoni G, Forconi F, Santi A, Trentin L, Ambrosetti A et al. Simple genetic diagnosis of hairy cell leukemia by sensitive detection of the BRAF-V600E mutation. Blood 2012; 119: 192–195.

    Article  CAS  Google Scholar 

  6. Basso K, Sumazin P, Morozov P, Schneider C, Maute RL, Kitagawa Y et al. Identification of the human mature B cell miRNome. Immunity 2009; 30: 744–752.

    Article  CAS  Google Scholar 

  7. Eisen MB, Spellman PT, Brown PO, Botstein D . Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA 1998; 95: 14863–14868.

    Article  CAS  Google Scholar 

  8. Califano A, Stolovitzky G, Tu Y . Analysis of gene expression microarrays for phenotype classification. Proc Int Conf Intell Syst Mol Biol 2000; 8: 75–85.

    CAS  PubMed  Google Scholar 

  9. le Sage C, Nagel R, Egan DA, Schrier M, Mesman E, Mangiola A et al. Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation. EMBO J 2007; 26: 3699–3708.

    Article  CAS  Google Scholar 

  10. Chilosi M, Chiarle R, Lestani M, Menestrina F, Montagna L, Ambrosetti A et al. Low expression of p27 and low proliferation index do not correlate in hairy cell leukaemia. Br J Haematol 2000; 111: 263–271.

    Article  CAS  Google Scholar 

  11. Lal A, Kim HH, Abdelmohsen K, Kuwano Y, Pullmann R, Srikantan S et al. p16(INK4a) translation suppressed by miR-24. PLoS One 2008; 3: e1864.

    Article  Google Scholar 

  12. Tsuchiya N, Izumiya M, Ogata-Kawata H, Okamoto K, Fujiwara Y, Nakai M et al. Tumor suppressor miR-22 determines p53-dependent cellular fate through post-transcriptional regulation of p21. Cancer Res 2011; 71: 4628–4639.

    Article  CAS  Google Scholar 

  13. Saito T, Saetrom P . MicroRNAs—targeting and target prediction. N Biotechnol 2010; 27: 243–249.

    Article  CAS  Google Scholar 

  14. Huang da W, Sherman BT, Lempicki RA . Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 2009; 37: 1–13.

    Article  Google Scholar 

  15. Kamiguti AS, Harris RJ, Slupsky JR, Baker PK, Cawley JC, Zuzel M . Regulation of hairy-cell survival through constitutive activation of mitogen-activated protein kinase pathways. Oncogene 2003; 22: 2272–2284.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

BF was supported by an investigator grant from the Associazione Italiana Ricerca sul Cancro and ET was supported by a fellowship (2008/14) from the European Hematology Association. We thank Roberta Pacini and Gianluca Schiavoni for their technical assistance.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to B Falini.

Ethics declarations

Competing interests

BF and ET applied for a patent on the clinical use of the BRAF V600E mutant in HCL. The remaining authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kitagawa, Y., Brahmachary, M., Tiacci, E. et al. A microRNA signature specific for hairy cell leukemia and associated with modulation of the MAPK–JNK pathways. Leukemia 26, 2564–2567 (2012). https://doi.org/10.1038/leu.2012.149

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/leu.2012.149

This article is cited by

Search

Quick links