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MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte–erythroid progenitor lineage commitment

Leukemia volume 26, pages 2310–2316 (2012)Cite this article

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Abstract

MicroRNAs (miRNAs) are a class of small regulatory noncoding RNAs that modulate the expression of their target genes through either mRNA degradation or inhibition of protein translation. In recent years, miRNAs have been shown to be critical regulators of hematopoiesis and have important roles in the differentiation of specific lineages. Here, we summarize our current understanding of miRNAs involved in hematopoiesis with a focus on the role of miRNAs in regulating erythroid and megakaryocytic differentiation and megakaryocyte–erythroid progenitor lineage commitment.

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Acknowledgements

LZ was supported by a graduate fellowship from the Singapore-Massachusetts Institute of Technology Alliance. VGS received support from NIH grant T32HL007574-30 and funds provided by the Department of Medicine at the Children’s Hospital Boston. This work was supported by SMA grant C-382-641-001-091 (to HFL), and NIH grants DK047618, DK068348 and 5P01 HL066105 (to HFL).

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Author notes

  1. L Zhang and V G Sankaran: These authors contributed equally to this work.

Authors and Affiliations

  1. Whitehead Institute for Biomedical Research, Cambridge, MA, USA

    L Zhang, V G Sankaran & H F Lodish

  2. Computation and Systems Biology, Singapore-Massachusetts Institute of Technology Alliance, Singapore, Singapore

    L Zhang

  3. Stem Cell and Developmental Biology, Genome Institute of Singapore, Singapore

    L Zhang

  4. Broad Institute, Cambridge, MA, USA

    V G Sankaran

  5. Department of Medicine, Children’s Hospital Boston, Boston, MA, USA

    V G Sankaran

  6. Department of Pediatrics, Harvard Medical School, Boston, MA, USA

    V G Sankaran

  7. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA

    H F Lodish

  8. Department of Bioengineering, Massachusetts Institute of Technology, Cambridge, MA, USA

    H F Lodish

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  1. L Zhang
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Correspondence to H F Lodish.

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Zhang, L., Sankaran, V. & Lodish, H. MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte–erythroid progenitor lineage commitment. Leukemia 26, 2310–2316 (2012). https://doi.org/10.1038/leu.2012.137

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  • DOI: https://doi.org/10.1038/leu.2012.137

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