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Phase I study of the anti insulin-like growth factor 1 receptor (IGF-1R) monoclonal antibody, AVE1642, as single agent and in combination with bortezomib in patients with relapsed multiple myeloma

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References

  1. Sprynski AC, Hose D, Caillot L, Reme T, Shaughnessy Jr JD, Barlogie B et al. The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor. Blood 2009; 113: 4614–4626.

    Article  CAS  Google Scholar 

  2. Mitsiades CS, Mitsiades NS, McMullan CJ, Poulaki V, Shringarpure R, Akiyama M et al. Inhibition of IGF-1 receptor tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors. Cancer Cell 2004; 5: 221–230.

    Article  CAS  Google Scholar 

  3. Bataille R, Robillard N, Avet-Loiseau H, Harousseau JL, Moreau P . CD221 (IGF-1R) is aberrantly expressed in multiple myeloma, in relation to disease severity. Haematologica 2005; 90: 706–707.

    CAS  Google Scholar 

  4. Descamps G, Gomez-Bougie P, Venot C, Moreau P, Bataille R, Amiot M . A humanised anti-IGF-1R monoclonal antibody (AVE1642) enhances bortezomib-induced apoptosis in myeloma cells lacking CD45. Br J Cancer 2009; 100: 366–369.

    Article  CAS  Google Scholar 

  5. Maloney EK, McLaughlin JL, Dagdigian NE, Garrett LM, Connors KM, Zhou XM et al. An anti-insulin-like growth factor I receptor antibody that is a potent inhibitor of cancer cell proliferation. Cancer Res 2003; 63: 5073–5083.

    CAS  PubMed  Google Scholar 

  6. Girard P, Boissel JP . Clockwise hysteresis or proteresis. J Pharmacokinet Biopharm 1989; 17: 401–402.

    Article  CAS  Google Scholar 

  7. Moreau P, Robillard N, Avet-Loiseau H, Pineau D, Morineau N, Milpied N et al. Patients with CD45 negative multiple myeloma receiving high-dose therapy have a shorter survival than those with CD45 positive multiple myeloma. Haematologica 2004; 89: 547–551.

    Google Scholar 

  8. Descamps G, Wuillème-Toumi S, Trichet V, Venot C, Debussche L, Hercend T et al. CD45neg but not CD45pos human myeloma cells are sensitive to the inhibition of IGF-1 signaling by a murine anti-IGF-1R monoclonal antibody, mAVE1642. J Immunol 2006; 177: 4218–4223.

    Article  CAS  Google Scholar 

  9. Sprynski AC, Hose D, Kassambara A, Vincent L, Jourdan M, Rossi JF et al. Insulin is a potent myeloma cell growth factor through insulin/IGF-1 hybrid receptor activation. Leukemia 2010; 24: 1940–1950.

    Article  CAS  Google Scholar 

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Moreau, P., Cavallo, F., Leleu, X. et al. Phase I study of the anti insulin-like growth factor 1 receptor (IGF-1R) monoclonal antibody, AVE1642, as single agent and in combination with bortezomib in patients with relapsed multiple myeloma. Leukemia 25, 872–874 (2011). https://doi.org/10.1038/leu.2011.4

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