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Chronic Lymphocytic Leukemia

Hematopoietic stem cell transplantation in T-prolymphocytic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation and the Royal Marsden Consortium

Leukemia volume 26, pages 972–976 (2012)Cite this article

Abstract

T-prolymphocytic leukemia (T-PLL) has a very poor prognosis with conventional immunochemotherapy. Incidental reports suggest that allogeneic hematopoietic stem cell transplantation (allo-HSCT) might have a role in this disease. Therefore, the purpose of the present study was to analyze the outcome of transplants for T-PLL registered with the European Group for Blood and Marrow Transplantation database and the Royal Marsden Consortium. Eligible were 41 patients with a median age of 51 (24–71) years; median time from diagnosis to treatment was 12 months, and in complete remission (CR) (11), partial remission (PR) (12), stable or progressive disease (13) and unknown in 5 patients. A total of 13 patients (31%) received reduced-intensity conditioning. Donors were HLA-identical siblings in 21 patients, matched unrelated donors in 20 patients. With a median follow-up of surviving patients of 36 months, 3-year relapse-free survival (RFS) and OS was 19% (95% CI, 6–31%) and 21% (95% CI, 7–34%), respectively. Multivariate analysis identified TBI and a short interval between diagnosis and HSCT as factors associated with favorable RFS. Three-year non relapse mortality and relapse incidence were each 41% with the majority of relapses occurring within the first year. These data indicate that allo-HSCT may provide effective disease control in selected patients with T-PLL.

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Acknowledgements

We acknowledge all collaborating EBMT Investigators and Institutions that contributed cases to this study listed in the Appendix. Moreover, we also acknowledge Investigators and Centers that were consulted and whose cases were disqualified from the analysis.

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Authors and Affiliations

  1. Department of Hematology, Oncology and Internal Diseases, Medical University, Warsaw, Poland

    W Wiktor-Jedrzejczak

  2. Royal Marsden Hospital, London, UK

    C Dearden

  3. Department of Medical Statistics and Bioinformatics, LUMC Leiden, The Netherlands

    L de Wreede & A van Biezen

  4. Hematology, Rikshospitalet, The National Hospital, Oslo, Norway

    L Brinch

  5. Hopital Pitie-Salpetriere, Paris, France

    V Leblond

  6. Sahlgrenska University Hospital, Goeteborg, Sweden

    M Brune

  7. University of Helsinki, Helsinki, Finland

    L Volin

  8. Hematology, Guy's Hospital, London, UK

    M Kazmi

  9. Chaim Cheba Medical Center, Tel-Hashomer, Israel

    A Nagler

  10. University Hospital of the Technical University Dresden, Dresden, Germany

    J Schetelig

  11. University Medical Center, Nijmegen, The Netherlands

    T de Witte

  12. University of Heidelberg, Heidelberg, Germany

    P Dreger

Authors
  1. W Wiktor-Jedrzejczak
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  2. C Dearden
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  5. L Brinch
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  6. V Leblond
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  7. M Brune
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  8. L Volin
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  9. M Kazmi
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  10. A Nagler
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  11. J Schetelig
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  12. T de Witte
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  13. P Dreger
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Consortia

on behalf of the EBMT Chronic Leukemia Working Party

Corresponding author

Correspondence to W Wiktor-Jedrzejczak.

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The authors declare no conflict of interest.

Appendix

Appendix

Table A1

Table a1 List of participating investigators
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Wiktor-Jedrzejczak, W., Dearden, C., de Wreede, L. et al. Hematopoietic stem cell transplantation in T-prolymphocytic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation and the Royal Marsden Consortium. Leukemia 26, 972–976 (2012). https://doi.org/10.1038/leu.2011.304

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