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Calle EE, Rodrigues C, Walker-Thurmond K, Thun MJ . Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 2003; 348: 1625–1638.
Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M . Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 2008; 371: 569–578.
Wolin KY, Carson K, Colditz GA . Obesity and cancer. Oncologist 2010; 15: 556–563.
Larsson SC, Wolk A . Excess body fatness: an important cause of most cancers. Lancet 2008; 371: 536–537.
Pan SY, Johnson KC, Ugnat AM, Wen SW, Mao Y . Canadian Cancer Registries Epidemiology Research Group. Association of obesity and cancer risk in Canada. Am J Epidemiol 2004; 159: 259–268.
Reeves GK, Pirie K, Beral V, Green J, Spencer E, Bull D . Cancer incidence and mortality in relation to body mass index in the Million Women Study: cohort study. BMJ 2007; 335: 1134.
Renehan AG, Soerjomataram I, Tyson M, Egger M, Zwahlen M, Coebergh JW et al. Incident cancer burden attributable to excess body mass index in 30 European countries. Int J Cancer 2010; 126: 692–702.
Wallin A, Larsson SC . Body mass index and risk of multiple myeloma: a meta-analysis of prospective studies. Eur J Cancer 2011; 47: 1606–1615.
Landgren O, Rajkumar SV, Pfeiffer RM, Kyle RA, Katzmann JA, Dispenzieri A et al. Obesity is associated with an increased risk of monoclonal gammopathy of undetermined significance among black and white women. Blood 2010; 116: 1056–1059.
Larsson SC, Wolk A . Overweight and obesity and incidence of leukemia: a meta-analysis of cohort studies. Int J Cancer 2008; 122: 1418–1421.
Lichtman MA . Is there an entity of chemically induced BCR-ABL-positive chronic myelogenous leukemia? Oncologist 2008; 13: 645–654.
MacInnis RJ, English DR, Hopper JL, Giles GG . Body size and composition and the risk of lymphohematopoietic malignancies. J Natl Cancer Inst 2005; 97: 1154–1157.
Engeland A, Tretli S, Hansen S, Bjørge T . Height and body mass index and risk of lymphohematopoietic malignancies in two million Norwegian men and women. Am J Epidemiol 2007; 165: 44–52.
Samanic C, Gridley G, Chow WH, Lubin J, Hoover RN, Fraumeni Jr JF . Obesity and cancer risk among white and black United States veterans. Cancer Causes Control 2004; 15: 35–43.
Fernberg P, Odenbro A, Bellocco R, Boffetta P, Pawitan Y, Zendehdel K et al. Tobacco use, body mass index, and the risk of leukemia and multiple myeloma: a nationwide cohort study in Sweden. Cancer Res 2007; 672: 5983–5986.
Kasim K, Levallois P, Abdous B, Auger P, Johnson KC . Lifestyle factors and the risk of adult leukemia in Canada. Cancer Causes Control 2005; 16: 489–500.
Söderberg KC, Kaprio J, Verkasalo PK, Pukkala E, Koskenvuo M, Lundqvist E et al. Overweight, obesity and risk of haematological malignancies: a cohort study of Swedish and Finnish twins. Eur J Cancer 2009; 45: 1232–1238.
Strom SS, Yamamura Y, Kantarijian HM, Cortes-Franco JE . Obesity, weight gain, and risk of chronic myeloid leukemia. Cancer Epidemiol Biomarkers Prev 2009; 18: 1501–1506.
Hursting SD, Lashinger LM, Wheatley KW, Rogers CJ, Colbert LH, Nunez NP et al. Reducing the weight of cancer: mechanistic targets for breaking the obesity-carcinogenesis link. Best Pract Res Clin Endocrinol Metab 2008; 22: 659–669.
Roberts DL, Dive C, Renehan AG . Biological mechanisms linking obesity and cancer risk: new perspectives. Annu Rev Med 2010; 61: 301–316.
Konopleva M, Mikhail A, Estrov Z, Zhao S, Harris D, Sanchez-Williams G et al. Expression and function of leptin receptor isoforms in myeloid leukemia and myelodysplastic syndromes: proliferative and anti-apoptotic activities. Blood 1999; 93: 1668–1676.
Gainsford T, Willson TA, Metcalf D, Handman E, McFarlane C, Ng A et al. Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc Natl Acad Sci USA 1996; 93: 14564–14568.
Fantuzzi G, Faggioni R . Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol 2000; 68: 437–446.
Shimon I, Shpilberg O . The insulin-like growth factor system in regulation of normal and malignant hematopoiesis. Leuk Res 1995; 19: 233–240.
The author has served as a medical expert for the defense in toxic tort cases and, in that context, has relied on research studies of obesity as a risk factor for the development of a hematological malignancy.
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Lichtman, M. Obesity and the risk of chronic myelogenous leukemia: is this another example of the neoplastic effects of increased body fat?. Leukemia 26, 183–184 (2012). https://doi.org/10.1038/leu.2011.190