Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Epstein-Barr virus microRNAs repress BCL6 expression in diffuse large B-cell lymphoma

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1
Figure 2

References

  1. Swerdlow SHCE, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (eds). WHO Classification: Pathology and Genetics of Tumors of Haematopoietic and Lymphoid Tissues. IARC Press: Lyon, 2008.

    Google Scholar 

  2. Perez-Rosado A, Artiga M, Vargiu P, Sanchez-Aguilera A, Alvarez-Barrientos A, Piris M . BCL6 represses NFkappaB activity in diffuse large B-cell lymphomas. J Pathol 2008; 214: 498–507.

    Article  CAS  Google Scholar 

  3. Carbone A, Gaidano G, Gloghini A, Pastore C, Saglio G, Tirelli U et al. BCL-6 protein expression in AIDS-related non-Hodgkin's lymphomas: inverse relationship with Epstein-Barr virus-encoded latent membrane protein-1 expression. Am J Pathol 1997; 150: 155–165.

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Pfeffer S, Zavolan M, Grasser FA, Chien M, Russo JJ, Ju J et al. Identification of virus-encoded microRNAs. Science 2004; 304: 734–736.

    Article  CAS  Google Scholar 

  5. Ferry JA . Burkitt's lymphoma: clinicopathologic features and differential diagnosis. Oncologist 2006; 11: 375–383.

    Article  Google Scholar 

  6. Shaffer AL, Lin KI, Kuo TC, Yu X, Hurt EM, Rosenwald A et al. Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. Immunity 2002; 17: 51–62.

    Article  CAS  Google Scholar 

  7. Vasanwala FH, Kusam S, Toney LM, Dent AL . Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene. J Immunol 2002; 169: 1922–1929.

    Article  CAS  Google Scholar 

  8. Keller SA, Hernandez-Hopkins D, Vider J, Ponomarev V, Hyjek E, Schattner EJ et al. NF-kappaB is essential for the progression of KSHV- and EBV-infected lymphomas in vivo. Blood 2006; 107: 3295–3302.

    Article  CAS  Google Scholar 

  9. Davis RE, Brown KD, Siebenlist U, Staudt LM . Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells. J Exp Med 2001; 194: 1861–1874.

    Article  CAS  Google Scholar 

  10. Mosialos G, Birkenbach M, Yalamanchili R, VanArsdale T, Ware C, Kieff E . The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell 1995; 80: 389–399.

    Article  CAS  Google Scholar 

  11. Cahir McFarland ED, Izumi KM, Mosialos G . Epstein-barr virus transformation: involvement of latent membrane protein 1-mediated activation of NF-kappaB. Oncogene 1999; 18: 6959–6964.

    Article  CAS  Google Scholar 

  12. Cahir-McFarland ED, Carter K, Rosenwald A, Giltnane JM, Henrickson SE, Staudt LM et al. Role of NF-kappa B in cell survival and transcription of latent membrane protein 1-expressing or Epstein-Barr virus latency III-infected cells. J Virol 2004; 78: 4108–4119.

    Article  CAS  Google Scholar 

  13. Klapproth K, Sander S, Marinkovic D, Baumann B, Wirth T . The IKK2/NF-{appa}B pathway suppresses MYC-induced lymphomagenesis. Blood 2009; 114: 2448–2458.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We would like to acknowledge all members of CNIOs Lymphoma Group for their thoughtful discussion. This study was funded with the following grants: from Ministerio de Educación y Ciencia, Spain SAF2007-65957-C02-02, SAF2008-03871; from the Fondo de Investigaciones Sanitarias, RTICC RD06/0020/0107 and PI10/00621; from Fundación Científica de la Asociación Española Contra el Cáncer (AECC). LDL is supported by a fellowship from Ministerio de Sanidad y Consumo (FI08/00038); NM is supported by a contract from Ministerio de Sanidad y Consumo (CP06/00002).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to M A Piris.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Additional information

Supplementary Information accompanies the paper on the Leukemia website

Supplementary information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Martín-Pérez, D., Vargiu, P., Montes-Moreno, S. et al. Epstein-Barr virus microRNAs repress BCL6 expression in diffuse large B-cell lymphoma. Leukemia 26, 180–183 (2012). https://doi.org/10.1038/leu.2011.189

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/leu.2011.189

This article is cited by

Search

Quick links