Coexistence of trisomies of chromosomes 12 and 19 in chronic lymphocytic leukemia occurs exclusively in the rare IgG-positive variant

Article metrics

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1


  1. 1

    Dohner H, Stilgenbauer S, Benner A, Leupolt E, Krober A, Bullinger L et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000; 343: 1910–1916.

  2. 2

    Athanasiadou A, Stamatopoulos K, Tsompanakou A, Gaitatzi M, Kalogiannidis P, Anagnostopoulos A et al. Clinical, immunophenotypic, and molecular profiling of trisomy 12 in chronic lymphocytic leukemia and comparison with other karyotypic subgroups defined by cytogenetic analysis. Cancer Genet Cytogenet 2006; 168: 109–119.

  3. 3

    Juliusson G, Merup M . Cytogenetics in chronic lymphocytic leukemia. Semin Oncol 1998; 25: 19–26.

  4. 4

    Schwaenen C, Nessling M, Wessendorf S, Salvi T, Wrobel G, Radlwimmer B et al. Automated array-based genomic profiling in chronic lymphocytic leukemia: development of a clinical tool and discovery of recurrent genomic alterations. Proc Natl Acad Sci USA 2004; 101: 1039–1044.

  5. 5

    Sellmann L, Gesk S, Walter C, Ritgen M, Harder L, Martin-Subero JI et al. Trisomy 19 is associated with trisomy 12 and mutated IGHV genes in B-chronic lymphocytic leukaemia. Br J Haematol 2007; 138: 217–220.

  6. 6

    Athanasiadou A, Stamatopoulos K, Gaitatzi M, Stavroyianni N, Fassas A, Anagnostopoulos A . Recurrent cytogenetic findings in subsets of patients with chronic lymphocytic leukemia expressing IgG-switched stereotyped immunoglobulins. Haematologica 2008; 93: 473–474.

  7. 7

    Martin-Subero JI, Ibbotson R, Klapper W, Michaux L, Callet-Bauchu E, Berger F et al. A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation. Leukemia 2007; 21: 1532–1544.

  8. 8

    Chapiro E, Radford-Weiss I, Bastard C, Luquet I, Lefebvre C, Callet-Bauchu E et al. The most frequent t(14;19)(q32;q13)-positive B-cell malignancy corresponds to an aggressive subgroup of atypical chronic lymphocytic leukemia. Leukemia 2008; 22: 2123–2127.

Download references


This work was supported by the Greek Ministry of Health; the ENosAI project (code 09SYN-13-880), co-funded by the EU and the Greek General Secretariat for Research and Technology; the Nordic Cancer Union, the Swedish Cancer Society and the Swedish Medical Research Council.

Author information

Correspondence to K Stamatopoulos.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Additional information

Author contributions

Rachel Ibbotson and Anastasia Athanasiadou performed research, analyzed the data and wrote the paper. Lesley-Ann Sutton, Zadie Davis, Anne Gardiner, Panagiotis Baliakas and Rebeqa Gunnarsson performed research. Achilles Anagnostopoulos and Gunnar Juliusson supervised research. Richard Rosenquist, David Oscier and Kostas Stamatopoulos designed the study, supervised research and wrote the paper.

Supplementary Information accompanies the paper on the Leukemia website

Supplementary information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ibbotson, R., Athanasiadou, A., Sutton, L. et al. Coexistence of trisomies of chromosomes 12 and 19 in chronic lymphocytic leukemia occurs exclusively in the rare IgG-positive variant. Leukemia 26, 170–172 (2012) doi:10.1038/leu.2011.186

Download citation

Further reading