Subscribe to Journal
Get full journal access for 1 year
only $102.00 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
All prices are NET prices.
Dohner H, Stilgenbauer S, Benner A, Leupolt E, Krober A, Bullinger L et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000; 343: 1910–1916.
Athanasiadou A, Stamatopoulos K, Tsompanakou A, Gaitatzi M, Kalogiannidis P, Anagnostopoulos A et al. Clinical, immunophenotypic, and molecular profiling of trisomy 12 in chronic lymphocytic leukemia and comparison with other karyotypic subgroups defined by cytogenetic analysis. Cancer Genet Cytogenet 2006; 168: 109–119.
Juliusson G, Merup M . Cytogenetics in chronic lymphocytic leukemia. Semin Oncol 1998; 25: 19–26.
Schwaenen C, Nessling M, Wessendorf S, Salvi T, Wrobel G, Radlwimmer B et al. Automated array-based genomic profiling in chronic lymphocytic leukemia: development of a clinical tool and discovery of recurrent genomic alterations. Proc Natl Acad Sci USA 2004; 101: 1039–1044.
Sellmann L, Gesk S, Walter C, Ritgen M, Harder L, Martin-Subero JI et al. Trisomy 19 is associated with trisomy 12 and mutated IGHV genes in B-chronic lymphocytic leukaemia. Br J Haematol 2007; 138: 217–220.
Athanasiadou A, Stamatopoulos K, Gaitatzi M, Stavroyianni N, Fassas A, Anagnostopoulos A . Recurrent cytogenetic findings in subsets of patients with chronic lymphocytic leukemia expressing IgG-switched stereotyped immunoglobulins. Haematologica 2008; 93: 473–474.
Martin-Subero JI, Ibbotson R, Klapper W, Michaux L, Callet-Bauchu E, Berger F et al. A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation. Leukemia 2007; 21: 1532–1544.
Chapiro E, Radford-Weiss I, Bastard C, Luquet I, Lefebvre C, Callet-Bauchu E et al. The most frequent t(14;19)(q32;q13)-positive B-cell malignancy corresponds to an aggressive subgroup of atypical chronic lymphocytic leukemia. Leukemia 2008; 22: 2123–2127.
This work was supported by the Greek Ministry of Health; the ENosAI project (code 09SYN-13-880), co-funded by the EU and the Greek General Secretariat for Research and Technology; the Nordic Cancer Union, the Swedish Cancer Society and the Swedish Medical Research Council.
The authors declare no conflict of interest.
Rachel Ibbotson and Anastasia Athanasiadou performed research, analyzed the data and wrote the paper. Lesley-Ann Sutton, Zadie Davis, Anne Gardiner, Panagiotis Baliakas and Rebeqa Gunnarsson performed research. Achilles Anagnostopoulos and Gunnar Juliusson supervised research. Richard Rosenquist, David Oscier and Kostas Stamatopoulos designed the study, supervised research and wrote the paper.
Supplementary Information accompanies the paper on the Leukemia website
About this article
Cite this article
Ibbotson, R., Athanasiadou, A., Sutton, L. et al. Coexistence of trisomies of chromosomes 12 and 19 in chronic lymphocytic leukemia occurs exclusively in the rare IgG-positive variant. Leukemia 26, 170–172 (2012) doi:10.1038/leu.2011.186
Cytogenetic complexity in chronic lymphocytic leukemia: definitions, associations, and clinical impact
Mutational and cytogenetic analyses of 188 CLL patients with trisomy 12: A retrospective study from the French Innovative Leukemia Organization (FILO) working group
Genes, Chromosomes and Cancer (2018)
Advances in Molecular Pathology (2018)
Assessing copy number aberrations and copy-neutral loss-of-heterozygosity across the genome as best practice: An evidence-based review from the Cancer Genomics Consortium (CGC) working group for chronic lymphocytic leukemia
Cancer Genetics (2018)