Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter to the Editor
  • Published:

Coexistence of trisomies of chromosomes 12 and 19 in chronic lymphocytic leukemia occurs exclusively in the rare IgG-positive variant

Leukemia volume 26, pages 170–172 (2012)Cite this article

Most cases of chronic lymphocytic leukemia (CLL) express surface immunoglobulin (Ig)M and surface IgD at levels lower than normal B cells. IgG-positive CLL is a relatively rare variant of CLL (frequency 6–10%), whose origin and ontogenetic relationship to the common IgM/IgD variant remains unknown.

Important biological and prognostic information in CLL is obtained by cytogenetic analysis. In particular, certain recurrent cytogenetic aberrations in CLL have been associated with different clinical outcomes; for instance, abnormalities of chromosome 17p are associated with poor prognosis, whereas deletions of chromosome 13q are associated with a favorable prognosis.1

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

References

  1. Dohner H, Stilgenbauer S, Benner A, Leupolt E, Krober A, Bullinger L et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000; 343: 1910–1916.

    Article  CAS  Google Scholar 

  2. Athanasiadou A, Stamatopoulos K, Tsompanakou A, Gaitatzi M, Kalogiannidis P, Anagnostopoulos A et al. Clinical, immunophenotypic, and molecular profiling of trisomy 12 in chronic lymphocytic leukemia and comparison with other karyotypic subgroups defined by cytogenetic analysis. Cancer Genet Cytogenet 2006; 168: 109–119.

    Article  CAS  Google Scholar 

  3. Juliusson G, Merup M . Cytogenetics in chronic lymphocytic leukemia. Semin Oncol 1998; 25: 19–26.

    CAS  PubMed  Google Scholar 

  4. Schwaenen C, Nessling M, Wessendorf S, Salvi T, Wrobel G, Radlwimmer B et al. Automated array-based genomic profiling in chronic lymphocytic leukemia: development of a clinical tool and discovery of recurrent genomic alterations. Proc Natl Acad Sci USA 2004; 101: 1039–1044.

    Article  CAS  Google Scholar 

  5. Sellmann L, Gesk S, Walter C, Ritgen M, Harder L, Martin-Subero JI et al. Trisomy 19 is associated with trisomy 12 and mutated IGHV genes in B-chronic lymphocytic leukaemia. Br J Haematol 2007; 138: 217–220.

    Article  Google Scholar 

  6. Athanasiadou A, Stamatopoulos K, Gaitatzi M, Stavroyianni N, Fassas A, Anagnostopoulos A . Recurrent cytogenetic findings in subsets of patients with chronic lymphocytic leukemia expressing IgG-switched stereotyped immunoglobulins. Haematologica 2008; 93: 473–474.

    Article  Google Scholar 

  7. Martin-Subero JI, Ibbotson R, Klapper W, Michaux L, Callet-Bauchu E, Berger F et al. A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation. Leukemia 2007; 21: 1532–1544.

    Article  CAS  Google Scholar 

  8. Chapiro E, Radford-Weiss I, Bastard C, Luquet I, Lefebvre C, Callet-Bauchu E et al. The most frequent t(14;19)(q32;q13)-positive B-cell malignancy corresponds to an aggressive subgroup of atypical chronic lymphocytic leukemia. Leukemia 2008; 22: 2123–2127.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by the Greek Ministry of Health; the ENosAI project (code 09SYN-13-880), co-funded by the EU and the Greek General Secretariat for Research and Technology; the Nordic Cancer Union, the Swedish Cancer Society and the Swedish Medical Research Council.

Author information

Authors and Affiliations

  1. Haematology Department, Royal Bournemouth Hospital, Bournemouth, UK

    R Ibbotson, Z Davis, A Gardiner & D Oscier

  2. Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece

    A Athanasiadou, P Baliakas, A Anagnostopoulos & K Stamatopoulos

  3. Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

    L-A Sutton, R Gunnarsson & R Rosenquist

  4. Department of Laboratory Medicine, Stem Cell Center, Hematology and Transplantation, Lund University, Lund, Sweden

    G Juliusson

  5. Institute of Agrobiotechnology, Center for Research and Technology, Thessaloniki, Greece

    K Stamatopoulos

Authors
  1. R Ibbotson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A Athanasiadou
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L-A Sutton
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Z Davis
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A Gardiner
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. P Baliakas
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. R Gunnarsson
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. A Anagnostopoulos
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. G Juliusson
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. R Rosenquist
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. D Oscier
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. K Stamatopoulos
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to K Stamatopoulos.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Additional information

Author contributions

Rachel Ibbotson and Anastasia Athanasiadou performed research, analyzed the data and wrote the paper. Lesley-Ann Sutton, Zadie Davis, Anne Gardiner, Panagiotis Baliakas and Rebeqa Gunnarsson performed research. Achilles Anagnostopoulos and Gunnar Juliusson supervised research. Richard Rosenquist, David Oscier and Kostas Stamatopoulos designed the study, supervised research and wrote the paper.

Supplementary Information accompanies the paper on the Leukemia website

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ibbotson, R., Athanasiadou, A., Sutton, LA. et al. Coexistence of trisomies of chromosomes 12 and 19 in chronic lymphocytic leukemia occurs exclusively in the rare IgG-positive variant. Leukemia 26, 170–172 (2012). https://doi.org/10.1038/leu.2011.186

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/leu.2011.186

This article is cited by

Search

Advanced search

Quick links