Table 2 CD38 expression and IGHV gene mutational status in cases assigned to the +12,+19 subgroup (‘+12+19’) to cases exhibiting trisomy 12 yet without coexisting trisomy 19 (‘+12 non +19’) and cases negative for trisomy 12 (‘no +12’)

From: Coexistence of trisomies of chromosomes 12 and 19 in chronic lymphocytic leukemia occurs exclusively in the rare IgG-positive variant

  ‘+12+19’ ‘+12 non +19’ ‘No +12’ P-value
CD38+ cells>30% 16/19, 84.2% 136/241, 56.4% 111/561, 19.8% <0.001
Median % of CD38+ cells 95 72.5 55 <0.05a
IGHV gene identity to germline 98% 2/20, 10% 115/218, 52.7% 203/593, 34.2% <0.001
IGHV gene identity to germline 100% 0/20, 0% 94/218, 43.1% 145/593, 24.5% <0.001
  1. t-test: P=0.37 for comparison of ‘+12+19’ versus ‘12 isolated’; P=0.04 for comparison of subgroups ‘+12+19’ versus ‘no 12’; P=0.001 for comparison of subgroups ‘12 isolated’ versus ‘no 12’.