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References
Cipolleschi MG, Dello Sbarba P, Olivotto M . The role of hypoxia in the maintenance of hematopoietic stem cells. Blood 1993; 82: 2031–2037.
Fiegl M, Samudio I, Clise-Dwyer K, Burks JK, Mnjoyan Z, Andreeff M . CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure. Blood 2009; 113: 1504–1512.
Harrison JS, Rameshwar P, Chang V, Bandari P . Oxygen saturation in the bone marrow of healthy volunteers. Blood 2002; 99: 394.
Towatari M, Iida H, Tanimoto M, Iwata H, Hamaguchi M, Saito H . Constitutive activation of mitogen-activated protein kinase pathway in acute leukemia cells. Leukemia 1997; 11: 479–484.
Kornblau SM, Tibes R, Qiu YH, Chen W, Kantarjian HM, Andreeff M et al. Functional proteomic profiling of AML predicts response and survival. Blood 2009; 113: 154–164.
Kiel MJ, Morrison SJ . Uncertainty in the niches that maintain haematopoietic stem cells. Nat Rev Immunol 2008; 8: 290–301.
Parmar K, Mauch P, Vergilio JA, Sackstein R, Down JD . Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia. Proc Natl Acad Sci 2007; 104: 5431–5436.
Chen X, Resh MD . Activation of mitogen-activated protein kinase by membrane-targeted Raf chimeras is independent of raft localization. J Biol Chem 2001; 276: 34617–34623.
Peres C, Yart A, Perret B, Salles JP, Raynal P . Modulation of phosphoinositide 3-kinase activation by cholesterol level suggests a novel positive role for lipid rafts in lysophosphatidic acid signalling. FEBS Lett 2003; 534: 164–168.
Ravandi F, Cortes JE, Jones D, Faderl S, Garcia-Manero G, Konopleva MY et al. Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia. J Clin Oncol 2010; 28: 1856–1862.
Acknowledgements
We thank Seshagiri Duvvuri, Twee Tsao, Teresa McQueen and Leslie Calvert for technical support. This work was in part supported by a grant from the Deutsche Forschungsgesellschaft (Grant FI 1487 to MF) and supported by grants from the National Cancer Institute (PO1 CA055164, P30 CA016672) and the Paul and Mary Haas Chair in Genetics (to MA).
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Fiegl, M., Samudio, I., Mnjoyan, Z. et al. Physiological hypoxia promotes lipid raft and PI3K-dependent activation of MAPK 42/44 in leukemia cells. Leukemia 24, 1364–1367 (2010). https://doi.org/10.1038/leu.2010.94
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DOI: https://doi.org/10.1038/leu.2010.94
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