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Gene expression analysis reveals HOX gene upregulation in trisomy 8 AML

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  1. Paulsson K, Johansson B . Trisomy 8 as the sole chromosomal aberration in acute myeloid leukemia and myelodysplastic syndromes. Pathol Biol (Paris) 2007; 55: 37–48.

    Article  CAS  Google Scholar 

  2. Valk PJ, Verhaak RG, Beijen MA, Erpelinck CA, Barjesteh van Waalwijk van D, Boer JM et al. Prognostically useful gene-expression profiles in acute myeloid leukemia. New Engl J Med 2004; 350: 1617–1628.

    Article  CAS  PubMed  Google Scholar 

  3. Verhaak RG, Wouters BJ, Erpelinck CA, Abbas S, Beverloo HB, Lugthart S et al. Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling. Haematologica 2009; 94: 131–134.

    Article  PubMed  Google Scholar 

  4. Byrd JC, Mrozek K, Dodge RK, Carroll AJ, Edwards CG, Arthur DC et al. Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461). Blood 2002; 100: 4325–4336.

    Article  CAS  PubMed  Google Scholar 

  5. Argiropoulos B, Humphries RK . Hox genes in hematopoiesis and leukemogenesis. Oncogene 2007; 26: 6766–6776.

    Article  CAS  PubMed  Google Scholar 

  6. Krivtsov AV, Armstrong SA . MLL translocations, histone modifications and leukaemia stem-cell development. Nat Rev Cancer 2007; 7: 823–833.

    Article  CAS  PubMed  Google Scholar 

  7. Dorrance AM, Liu S, Yuan W, Becknell B, Arnoczky KJ, Guimond M et al. Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations. J Clin Invest 2006; 116: 2707–2716.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Mullighan CG, Kennedy A, Zhou X, Radtke I, Phillips LA, Shurtleff SA et al. Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias. Leukemia 2007; 21: 2000–2009.

    Article  CAS  PubMed  Google Scholar 

  9. Kornblau SM, Tibes R, Qiu YH, Chen W, Kantarjian HM, Andreeff M et al. Functional proteomic profiling of AML predicts response and survival. Blood 2009; 113: 154–164.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Costa BM, Smith JS, Chen Y, Chen J, Phillips HS, Aldape KD et al. Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma. Cancer Res 2010; 70: 453–462.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. De Santa F, Totaro MG, Prosperini E, Notarbartolo S, Testa G, Natoli G . The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Cell 2007; 130: 1083–1094.

    Article  CAS  PubMed  Google Scholar 

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CHK was supported by a scholarship from the Queen Elizabeth Hospital Research Foundation and ALB was a fellow of the Cancer Council of South Australia.

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Correspondence to R J D'Andrea.

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Kok, C., Brown, A., Ekert, P. et al. Gene expression analysis reveals HOX gene upregulation in trisomy 8 AML. Leukemia 24, 1239–1243 (2010).

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