Table 2 Presence of leukemic fusion genes (and hyperdiploidy) in BM-MSCs from a cohort of infants/children with cytogenetically distinct acute leukemia

From: Insights into the cellular origin and etiology of the infant pro-B acute lymphoblastic leukemia with MLL-AF4 rearrangement

Patient ID Diagnosis Cytogenetics (fusion gene) Age (months) Fusion gene in MSC (% positive MSCs) Positive cases in each diagnostic group
 1 PreB-ALL t(12;21) TEL-AML1 30 NO
 2 PreB-ALL t(12;21) TEL-AML1 24 NO
 3 PreB-ALL t(12;21) TEL-AML1 36 NO
 4 PreB-ALL t(12;21) TEL-AML1 42 NO
 5 PreB-ALL t(12;21) TEL-AML1 70 NO
 6 PreB-ALL t(12;21) TEL-AML1 84 NO 0/12 (0%)
 7 PreB-ALL t(12;21) TEL-AML1 42 NO
 8 PreB-ALL t(12;21) TEL-AML1 96 NO
 9 PreB-ALL t(12;21) TEL-AML1 60 NO
10 PreB-ALL t(12;21) TEL-AML1 48 NO
11 PreB-ALL t(12;21) TEL-AML1 30 NO
12 PreB-ALL t(12;21) TEL-AML1 54 NO
13 M2-AML t(8;21) AML1-ETO 144 NO 0/1 (0%)
14 PreB-ALL t(9;22) BCR–ABL 72 NO
15 PreB-ALL t(9;22) BCR–ABL 48 NO
16 PreB-ALL t(9;22) BCR–ABL 60 NO 0/5 (0%)
17 PreB-ALL t(9;22) BCR–ABL 72 NO
18 PreB-ALL t(9;22) BCR–ABL 72 NO
19 T-ALL Hyperdiploid 30 NO
20 PreB-ALL Hyperdiploid 48 NO
21 PreB-ALL Hyperdiploid 24 NO
22 PreB-ALL Hyperdiploid 36 NO
23 PreB-ALL Hyperdiploid 36 NO 0/10 (0%)
24 PreB-ALL Hyperdiploid 48 NO
25 PreB-ALL Hyperdiploid 142 NO
26 PreB-ALL Hyperdiploid 24 NO
27 PreB-ALL Hyperdiploid 60 NO
28 PreB-ALL Hyperdiploid 18 NO
29 Pro-B-ALL t(4;11) MLL-AF4 6 YES (4%)
30 Pro-B-ALL t(4;11) MLL-AF4 11 YES (7%) 4/4 (100%)
31 Pro-B-ALL t(4;11) MLL-AF4 6 YES (7%)
32 Pro-B-ALL t(4;11) MLL-AF4 4 YES (8%)
33 M5-AML t(9;11) MLL-AF9 180 NO
34 M5-AML t(9;11) MLL-AF9 12 NO
35 M2-AML t(9;11) MLL-AF9 7 NO 0/6 (0%)
36 M5-AML t(10;11) MLL-AF10 15 NO
37 PreB-ALL t(11;19) MLL-ENL 7 NO
38 AML t(11;19) MLL-ENL 9 NO
  1. Abbreviation: ALL, acute lymphoblastic leukemia; AML: acute myeloid leukemia, BM-MSC, bone marrow mesenchymal stem cell; B-ALL, B-cell acute lymphoblastic leukemia; T-ALL, T-cell acute lymphoblastic leukemia. Note that all the MLL-AF4+ ALL patients are infants (<11 months old). Infantile pro-B-ALL cases are shown in bold.