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The anti-apoptotic gene BCL2A1 is a novel transcriptional target of PU.1

Leukemia volume 24, pages 1073–1076 (2010)Cite this article

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The transcription factor PU.1 is a key player in myeloid and B-cell development as evidenced by PU.1 knockout mouse models. PU.1 is necessary for the generation and function of macrophages and granulocytes through the regulation of essential myeloid genes such as the granulocyte/macrophage colony-stimulating factor receptor (GM-CSFR), the macrophage CSF (M-CSF), the granulocyte CSF (G-CSF), CD11b, myeloperoxidase, lysozyme, neutrophil elastase, CD45, and others.1, 2, 3

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Acknowledgements

We thank Deborah Shan, Judith Laedrach, and Gustav Arvidsson for expert technical support. This work was supported by grants from the Swiss National Science Foundation 3100A0-118276 (to MPT) and 3100A0-112385 (to MFF and AT), the Bern University Research Foundation (to MPT), the Werner and Hedy Berger-Janser Foundation of Cancer Research (to MFF and MPT), the NIH, HL091219 and DK54938, the Joyce Klein Stock Gift (to BET), the Marlies-Schwegler Foundation, the Ursula-Hecht-Foundation for Leukemia Research, and the Bernese Foundation of Cancer Research (to MFF).

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Authors and Affiliations

  1. Department of Clinical Research, Experimental Oncology/Hematology, University of Bern, Bern, Switzerland

    M Jenal, J Batliner, A Tobler, M F Fey & M P Tschan

  2. Cancer Stem Cell Program, Novartis Institute of Functional Genomics, San Diego, CA, USA

    V A Reddy

  3. MLL Munich Leukemia Laboratory, Munich, Germany

    T Haferlach

  4. Department of Hematology, Inselspital, Bern University Hospital, Bern, Switzerland

    A Tobler

  5. Department of Medical Oncology, Inselspital, Bern University Hospital, Bern, Switzerland

    M F Fey & M P Tschan

  6. Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA

    B E Torbett

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  1. M Jenal
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  2. J Batliner
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  7. B E Torbett
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  8. M P Tschan
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Correspondence to M P Tschan.

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Authorship

MJ designed the project, performed experiments, collected and analyzed all data, manuscript writing; JB was involved in knockdown experiments and expression analysis; VAR performed microarray analysis; TH provided AML samples, expression analysis; AT, MFF, and BET performed project planning and design, reviewed manuscript; MPT was the principal investigator and takes primary responsibility for the paper.

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Jenal, M., Batliner, J., Reddy, V. et al. The anti-apoptotic gene BCL2A1 is a novel transcriptional target of PU.1. Leukemia 24, 1073–1076 (2010). https://doi.org/10.1038/leu.2010.26

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