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TET2 mutations in childhood leukemia

Leukemia volume 25, pages 189–192 (2011)Cite this article

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The Ten-Eleven-Translocation 2 (TET2) gene has recently been implicated in a variety of hematopoietic malignancies in adults. Mutations and deletions were detected in myelodysplastic syndromes, acute myeloid leukemias (AML) and other myeloid malignancies.1, 2, 3, 4, 5 So far, however, the presence of TET2 mutations has not been reported in childhood leukemia.

Precursor B-cell acute lymphoblastic leukemia (ALL) and AML represent the most frequently occurring hematopoietic malignancies in children. During the past decades, the survival rates of children with these malignancies have improved considerably, but a substantial subset of the patients still suffers from relapses and treatment-related mortality. Genetic abnormalities may provide insights into the mechanisms underlying the etiology of leukemia and the development of therapy resistance. In addition, they may provide novel clues for the development of targeted therapies. TET2 mutations are found in 8–19% of adult AML,1, 5 and the expression of TET2 is high in granulocytes as compared with other hematopoietic and non-hematopoietic cells, where it is increased during myeloid differentiation.1 Also normal B-cells show high TET2 expression,1 but TET2 mutations in adult ALL have not been reported. Here, we set out to assess a cohort of childhood AMLs and precursor B-cell ALLs for the presence of mutations in TET2.

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References

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Acknowledgements

This work was supported by grants from ZonMW (to SMCL) and the Dutch Cancer Society (to RPK and AG and PMH).

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Authors and Affiliations

  1. Laboratory of Hematology, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands

    S M C Langemeijer, J H Jansen, P van Hoogen, E Stevens-Linders & M Massop

  2. Department of Human Genetics, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands

    J Hooijer, E Waanders, S V van Reijmersdal, M J P L Stevens-Kroef, A Geurts van Kessel & R P Kuiper

  3. Department of Pediatric Oncology/Hematology, Erasmus MC/Sophia Children's Hospital, Rotterdam, The Netherlands

    C M Zwaan

  4. Department of Hematology, University Hospital Dijkzigt and Erasmus University, Rotterdam, The Netherlands

    M M van den Heuvel-Eibrink

  5. Dutch Childhood Oncology Group, The Hague, The Netherlands

    E Sonneveld & P M Hoogerbrugge

  6. Department of Pediatric Hemato-Oncology, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands

    P M Hoogerbrugge

Authors
  1. S M C Langemeijer
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  6. M Massop
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  7. E Waanders
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  8. S V van Reijmersdal
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  13. P M Hoogerbrugge
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  14. A Geurts van Kessel
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  15. R P Kuiper
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Correspondence to R P Kuiper.

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The authors declare no conflict of interest.

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Langemeijer, S., Jansen, J., Hooijer, J. et al. TET2 mutations in childhood leukemia. Leukemia 25, 189–192 (2011). https://doi.org/10.1038/leu.2010.243

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