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Targeting heat shock protein 72 enhances Hsp90 inhibitor-induced apoptosis in myeloma

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Acknowledgements

We acknowledge NHS funding to the NIHR Biomedical Research Centre. This work was supported by the Kay Kendall Leukaemia Fund, Myeloma UK, Luck-Hille Foundation, Cancer Research UK Program Grant C309/A8274 and PW is a Cancer Research UK Life Fellow.

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Correspondence to F E Davies.

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The authors are employees of The Institute of Cancer Research, which has a commercial interest in Hsp90 inhibitors. The authors have been involved in funded research collaborations on Hsp90 inhibitors with Vernalis Ltd. and on chaperone and stress pathways with AstraZeneca. Intellectual property arising from the Hsp90 programme has been licensed to Vernalis and Novartis. PW has been a consultant to Novartis.

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Davenport, E., Zeisig, A., Aronson, L. et al. Targeting heat shock protein 72 enhances Hsp90 inhibitor-induced apoptosis in myeloma. Leukemia 24, 1804–1807 (2010). https://doi.org/10.1038/leu.2010.168

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