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Effects of MSC co-injection on the reconstitution of aplastic anemia patient following hematopoietic stem cell transplantation

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  1. Gluckman E, Horowitz MM, Champlin RE, Hows JM, Bacigalupo A, Biggs JC et al. Bone marrow transplantation for severe aplastic anemia: influence of conditioning and graft-versus-host disease prophylaxis regimens on outcome. Blood 1992; 79: 269–275.

    CAS  PubMed  Google Scholar 

  2. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284: 143–147.

    Article  CAS  Google Scholar 

  3. Ramasamy R, Tong CK, Seow HF, Vidyadaran S, Dazzi F . The immunosuppressive effects of human bone marrow-derived mesenchymal stem cells target T cell proliferation but not its effector function. Cell Immunol 2008; 251: 131–136.

    Article  CAS  Google Scholar 

  4. Le Blanc K, Ringden O . Use of mesenchymal stem cells for the prevention of immune complications of hematopoietic stem cell transplantation. Haematologica 2005; 90: 438.

    PubMed  Google Scholar 

  5. Fang B, Li N, Song Y, Li J, Zhao RC, Ma Y . Cotransplantation of haploidentical mesenchymal stem cells to enhance engraftment of hematopoietic stem cells and to reduce the risk of graft failure in two children with severe aplastic anemia. Pediatr Transplant 2009; 13: 499–502.

    Article  Google Scholar 

  6. Le Blanc K, Samuelsson H, Gustafsson B, Remberger M, Sundberg B, Arvidson J et al. Transplantation of mesenchymal stem cells to enhance engraftment of hematopoietic stem cells. Leukemia 2007; 21: 1733–1738.

    Article  CAS  Google Scholar 

  7. Campioni D, Rizzo R, Stignani M, Melchiorri L, Ferrari L, Moretti S et al. A decreased positivity for CD90 on human mesenchymal stromal cells (MSCs) is associated with a loss of immunosuppressive activity by MSCs. Cytometry B Clin Cytom 2009; 76: 225–230.

    Article  Google Scholar 

  8. Calvi LM, Adams GB, Weibrecht KW, Weber JM, Olson DP, Knight MC et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 2003; 425: 841–846.

    Article  CAS  Google Scholar 

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We thank Christopher Ridler for help with the animal experiments. These works were funded by Cancer Research UK and by European grant (contract No. LHSB-CT-2006-018817) to DB.

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Correspondence to D Bonnet.

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Jaganathan, B., Tisato, V., Vulliamy, T. et al. Effects of MSC co-injection on the reconstitution of aplastic anemia patient following hematopoietic stem cell transplantation. Leukemia 24, 1791–1795 (2010).

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