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The most commonly reported variant in ASXL1 (c.1934dupG;p.Gly646TrpfsX12) is not a somatic alteration

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  1. Gelsi-Boyer V, Trouplin V, Adelaide J, Bonansea J, Cervera N, Carbuccia N et al. Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia. Br J Haematol 2009; 145: 788–800.

    Article  CAS  Google Scholar 

  2. Boultwood J, Perry J, Pellagatti A, Fernandez-Mercado M, Fernandez-Santamaria C, Calasanz MJ et al. Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia. Leukemia 2010; 24: 1062–1065.

    Article  CAS  Google Scholar 

  3. Boultwood J, Perry J, Zaman R, Fernandez-Santamaria C, Littlewood T, Kusec R et al. High-density single nucleotide polymorphism array analysis and ASXL1 gene mutation screening in chronic myeloid leukemia during disease progression. Leukemia 2010; 24: 1139–1145.

    Article  CAS  Google Scholar 

  4. Carbuccia N, Murati A, Trouplin V, Brecqueville M, Adelaide J, Rey J et al. Mutations of ASXL1 gene in myeloproliferative neoplasms. Leukemia 2009; 23: 2183–2186.

    Article  CAS  Google Scholar 

  5. Carbuccia N, Trouplin V, Gelsi-Boyer V, Murati A, Rocquain J, Adelaide J et al. Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias. Leukemia 2010; 24: 469–473.

    Article  CAS  Google Scholar 

  6. Fazekas A, Steeves R, Newmaster SG . Improving sequencing quality from PCR products containing long mononucleotide repeats. BioTechniques 2010; 48: 351–355.

    Article  Google Scholar 

  7. Clarke LA, Rebelo CS, Goncalves J, Boavida MG, Jordan P . PCR amplification introduces errors into mononucleotide and dinucleotide repeat sequences. Mol Pathol 2001; 54: 351–353.

    Article  CAS  Google Scholar 

  8. Abdel-Wahab O, Manshouri T, Patel J, Harris K, Yao J, Hedvat C et al. Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias. Cancer Res 2010; 70: 447–452.

    Article  CAS  Google Scholar 

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Correspondence to R L Levine.

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Abdel-Wahab, O., Kilpivaara, O., Patel, J. et al. The most commonly reported variant in ASXL1 (c.1934dupG;p.Gly646TrpfsX12) is not a somatic alteration. Leukemia 24, 1656–1657 (2010). https://doi.org/10.1038/leu.2010.144

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