Survival analysis according to known recurrent aberrations and an increasing number of genomic aberrations (Kaplan–Meier plots). Kaplan–Meier survival analysis and the log-rank test were performed using the Statistica Software 8.0 (Stat Soft Inc., Tulsa, OK, USA). Overall survival was defined as time from diagnosis until date of last follow-up or death. Survival according to (a) known recurrent aberrations, overall P<0.00001. (b–d) Overall survival according to the degree of genomic complexity showed (b) no impact on survival by the number of CNAs <1 Mb (P=0.88), (c) a statistically significant difference between patients carrying an increasing number of CNAs between 1 and 5 Mbp (P=0.008), and (d) a worse outcome for patients carrying an increasing number of CNAs >5 Mbp (P=0.00002). Tick marks in Kaplan–Meier plots indicate censored follow-up.