Clinical outcomes of patients treated with total therapies (TT1, TT2 and TT3). Given are Kaplan–Meier plots of patients treated with TT1 (gold), TT2 without thalidomide (green), TT2 with thalidomide (red) and TT3 (blue). The four panels depict overall survival (top left), event-free survival (top right), time to stringently defined complete remission (s-CR; bottom left) and duration of s-CR from its onset (bottom right). The progressive improvement in the four clinical end points is readily appreciated with the transition from TT1 to TT2 to TT3. The plateau in the CR duration curve for TT1 from 10 years onward (bottom right panel, gold) is consistent with cure.