Figure 2 | Leukemia

Figure 2

From: CD34+CD38+CD19+ as well as CD34+CD38−CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL

Figure 2

Both CD34+CD38−CD19+ and CD34+CD38+CD19+ B-ALL cells have the ability to reconstitute B-ALL in vivo. Flow cytometric analyses of BM from representative recipients of each cell fraction from each case are shown. Left panels: gated on hCD45+ cells; middle panels: gated on hCD34+CD38− cells; right panels: gated on hCD34+CD38+ cells. For Case 1, 6.5 × 104 CD34+CD38+CD19+ and CD34+CD38−CD19+ were transplanted. For Case 2, 5.0 × 104 CD34+CD38+CD19+ and 4.0 × 104 CD34+CD38−CD19+ cells were transplanted. For Case 3, 2.5 × 104 CD34+CD38+CD19+ and 6.5 × 104 CD34+CD38−CD19+ cells were transplanted. ALL, acute lymphocytic leukemia; BM, bone marrow.

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