Table 4 Uses of serum immunoglobulin free light chain assay

From: International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders

Screening in combination with immunofixation electrophoresis 20
Baseline values prognostic
 Monoclonal gammopathy of undermined significance17
 Smoldering myeloma16
 Symptomatic myeloma9, 12, 29, 32
 AL amyloidosis28
Hematologic response
 AL amyloidosis19, 28, 34, 35, 36
 ‘Non-secretory’ myelomaa13
Stringent complete response in multiple myelomaa37
Light chain deposition disease (Personal experience of authors)
  1. aNot yet validated.