Table 2 Rates of abnormal FLC ratio in different plasma cell disorders

From: International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders

Disease n Abn rFLC, %
Multiple myeloma (MM)
 Symptomatic MM9 790 95
 Symptomatic MM10 456 96
 Symptomatic MM11 61 97
 Symptomatic MM12 399 96
 Non secretory MM13 28 68
 Non secretory MM14 5 100
 Light chain MM3 224 100
 Light chain MM15 28 100
 Smoldering MM14 72 88
 Smoldering MM16 273 90
MGUS17 1148 33
MGUS14 114 44
Amyloidosis18 95 92
Amyloidosis19 262 98
Amyloidosis14 110 91
Light chain deposition disease14 28 93
  1. Abbreviations: Abn, abnormal; FLC, immunoglobulin-free light chain; MGUS, monoclonal gammopathy of undetermined significance; rFLC, FLC ratio.