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Reduced intensity conditioning allogeneic stem cell transplantation for patients with acute myeloid leukemia: long term results of a ‘donor’ versus ‘no donor’ comparison

Leukemia volume 23, pages 194–196 (2009)Cite this article

Standard myeloablative allogeneic stem cell transplantation (allo-SCT) is a well-established therapy for patients with acute myeloid leukemia (AML). However, because of the high incidence of transplant-related mortality (TRM), this procedure is limited to younger patients in good medical condition.1 Reduced-intensity conditioning (RIC) regimens have emerged as an attractive modality to decrease TRM.2, 3 However, the issue of possible higher relapse rate after RIC-allo-SCT is still under debate,4, 5, 6 and no randomized studies between RIC-allo-SCT for AML and chemotherapy alone are yet available.7

This updated analysis describes the long-term results of 95 previously reported8 consecutive AML patients, diagnosed between 1999 and 2003 in a single institution, and who were considered as potential candidates for RIC-allo-SCT. Detailed methods were previously published.8 Using a genetic randomization through a ‘donor’ versus ‘no donor’ comparison, the aim of this updated analysis was to assess the benefit of RIC-allo-SCT for adult AML and its impact on clinical outcome. In this series, 35 patients (37%; ‘donor’ group) had an ‘identified’ HLA-identical sibling donor, while the remaining 60 patients had no HLA-matched related donor (‘no donor’ group). As per institutional policy, HLA-matched unrelated donors were not considered during the study period.8

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References

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Acknowledgements

We thank the nursing staff for providing excellent care for our patients and the physicians of the Hematology Department at the Institut Paoli-Calmettes for their important study contributions and dedicated patient care. We also thank the ‘Association pour la Recherche sur le Cancer (ARC)’ (Pole ARECA), the ‘Fondation de France’, the ‘Fondation contre la Leucémie’, the ‘Agence de Biomédecine’, the ‘Association Cent pour Sang la Vie’ and the ‘Association Laurette Fuguain’ for their generous and continuous support for our clinical and basic research work. We were supported by several grants from the French Ministry of Health as part of the ‘Programme Hospitalier de Recherche Clinique (PHRC)’.

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Authors and Affiliations

  1. Unité de Transplantation et de Thérapie Cellulaire (UTTC), Institut Paoli-Calmettes, Marseille, France

    M Mohty, H de Lavallade, J El-Cheikh, C Faucher, S Fürst & D Blaise

  2. Departement d'Hématologie, Institut Paoli-Calmettes, Marseille, France

    M Mohty, J El-Cheikh, C Faucher, S Fürst, N Vey, D Coso, A-M Stoppa, J-A Gastaut & D Blaise

  3. Faculté de Médecine, Université de la Méditerranée, Marseille, France

    M Mohty & D Blaise

  4. INSERM, UMR 599, Marseille, France

    M Mohty & D Blaise

  5. Institut Paoli-Calmettes, Centre de Thérapie Cellulaire et Génique (CTCG), Marseille, France

    P Ladaique & C Chabannon

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  1. M Mohty
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Correspondence to M Mohty.

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Mohty, M., de Lavallade, H., El-Cheikh, J. et al. Reduced intensity conditioning allogeneic stem cell transplantation for patients with acute myeloid leukemia: long term results of a ‘donor’ versus ‘no donor’ comparison. Leukemia 23, 194–196 (2009). https://doi.org/10.1038/leu.2008.164

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