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Reply to “Reply to ‘The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rates in hematologic malignancy patients: outcome of a pilot clinical study’ by Ning H et al.” by Behre et al.

Leukemia volume 23, pages 179–180 (2009)Cite this article

The questions raised by Behre et al.1 are important and further data and discussion will make these issues more clear. The study described in our paper2 was an open-labeled randomized clinical trial on cotransplantation of hematopoietic stem cells with or without culture-expanded mesenchymal stem cells (MSC) from the same donor in human leukocyte antigen (HLA)-identical sibling-matched hematopoietic stem cell transplantation. A total of 30 patients were enrolled and allocated into two groups by using stratified random method according to the enrolled time, age, disease types, stage and prognosis.

Firstly, Behre et al. think the transplantation of bone marrow (BM) as a cotransplantation of MSC. BM is well known as a major source of MSCs, but this population is rare (0.001–0.01%)3 and unlikely to exert potent immunosuppressive function, which is proven dose-dependent by many studies.4 Furthermore, MSCs have also been isolated and expanded from mobilized peripheral blood recently.5 Thus, we do not agree with Behre et al. that the patients who received BM or BM together with peripheral blood stem cells should be regrouped into MSC group, as they received a marrow graft containing MSC. In coincidence, several large randomized studies showed that the incidence of acute graft-versus-host disease was similar in the recipients of peripheral blood and those of bone marrow.6, 7

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References

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Authors and Affiliations

  1. Department of Hematopoietic Stem Cell Transplantation, Affiliated Hospital to Academy of Military Medical Sciences, Beijing, PR China

    H Ning, F Yang, M Jiang, L Hu, K Feng, J Zhang, Z Yu, B Li, C Xu, Y Li, J Wang, J Hu, X Lou & H Chen

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  1. H Ning
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Correspondence to H Chen.

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Ning, H., Yang, F., Jiang, M. et al. Reply to “Reply to ‘The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rates in hematologic malignancy patients: outcome of a pilot clinical study’ by Ning H et al.” by Behre et al.. Leukemia 23, 179–180 (2009). https://doi.org/10.1038/leu.2008.151

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