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The most frequent t(14;19)(q32;q13)-positive B-cell malignancy corresponds to an aggressive subgroup of atypical chronic lymphocytic leukemia

Leukemia volume 22, pages 2123–2127 (2008)Cite this article

The translocation t(14;19)(q32;q13) was described as recurrent in B-cell chronic lymphocytic leukemia (CLL) in 1985. The chromosomal rearrangement of the immunoglobulin heavy chain (IGH) gene locus resulted in upregulated expression of a new gene, named BCL3, encoding a protein member of the IκB family.1 It was then reported that t(14;19) was not entirely specific to CLL, because it was also found in other types of chronic B-cell malignancies (for review, see Soma et al.2). The Groupe Francophone de Cytogénétique Hématologique (GFCH) collected 43 chronic lymphoproliferative disorders with t(14;19) or variant BCL3-translocations between 1988 and 2007, to analyze to what extent this uncommon abnormality could define a subgroup among B-cell malignancies, and to document the consequences of the rearrangement.

Clinical and biological patients’ informations were gathered at diagnosis when available. There were 27 men and 16 women, with a median age of 62 years (range, 39–89 years). Thirty-three of 36 patients (92%) had an absolute lymphocytosis, with a median lymphocyte count of 24 × 109/l (range, 5.4–514 × 109/l). Seventeen of 39 patients (44%) had splenomegaly. Of the 25 CLL for whom Binet’ stage was available, there were 16 (64%) A stages, five (20%) B, four (16%) C. B/C stages were treated at diagnosis, 10 (62%) A stages required therapy quickly. The median of the time to treatment was 1, 2 months for all stages, 10 months for A stages (range, 0 month–7 years). Six of 20 were dead 3 years after diagnosis (Supplementary Table 1).

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Figure 1

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Acknowledgements

We gratefully acknowledge M Busson, J Ong and L Merlin for excellent technical assistance, F Gaillard for histopathological review, C Lesty for statistical analysis, and the other participants of each institute: K Maloum, S Choquet, S Daliphard, B Chetaille, E Bergoin, M Lessard, F Dupré, J-L Lai, D Mühlematter, P-Y Lovey, F Picard.

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Authors and Affiliations

  1. Service d’Hématologie Biologique, Assistance Publique-Hôpitaux de Paris Pitié-Salpêtrière, Paris, France

    E Chapiro, H Merle-Béral, F Davi & F Nguyen-Khac

  2. UPMC, Univ Paris 06, Paris, France

    E Chapiro, H Merle-Béral, F Davi & F Nguyen-Khac

  3. INSERM EMI0210, Necker-Enfants Malades, Paris, France

    E Chapiro, I Radford-Weiss, O A Bernard, R Berger & F Nguyen-Khac

  4. Laboratoire de Cytogénétique, CHU Necker-Enfants Malades, Paris, France

    I Radford-Weiss

  5. Laboratoire de Génétique Oncologique, Centre H Becquerel, Rouen, France

    C Bastard

  6. Service de Génétique, CHU Reims, Reims, France

    I Luquet

  7. Laboratoire d’Hématologie Cellulaire et Moléculaire, CHU Grenoble, Grenoble, France

    C Lefebvre & D Leroux

  8. Service d’Hématologie Biologique, CH Lyon Sud, Lyon, France

    E Callet-Bauchu & P Felman

  9. Oncohématologie, CHU Nantes, Nantes, France

    P Talmant

  10. Institut Paoli-Calmettes, Marseille, France

    M-J Mozziconacci

  11. Laboratoire de Cytogénétique, CHU Dijon, Dijon, France

    F Mugneret

  12. Laboratoire d’Hématologie, CHRU Strasbourg, Strasbourg, France

    S Struski

  13. Laboratoire d’oncohématologie, Hôpital Pasteur, Nice, France

    S Raynaud

  14. Laboratoire de Génétique Médicale, CHRU Lille, Lille, France

    J Andrieux

  15. Service de Génétique, CHU Tours, Tours, France

    C Barin

  16. Cytogénétique du Cancer, CHUV Lausanne, Lausanne, Suisse,

    M Jotterand

  17. Laboratoire Pasteur-Cerba, Cergy Pontoise, France

    H Mossafa

  18. Service d’Hématologie, CHU Hôtel-Dieu, Paris, France

    S Ramond

  19. Laboratoire de Cytogénétique, CH Versailles, Versailles, France

    C Terré

  20. Laboratoire de Cytogénétique, CHU Bordeaux, Bordeaux, France

    E Lippert

  21. Service d’Anatomopathologie, CH Lyon Sud, Lyon, France

    F Berger

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on behalf of the Groupe Francophone de Cytogénétique Hématologique (GFCH)

Corresponding author

Correspondence to F Nguyen-Khac.

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Supplementary Information accompanies the paper on the Leukemia website (http://www.nature.com/leu)

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Chapiro, E., Radford-Weiss, I., Bastard, C. et al. The most frequent t(14;19)(q32;q13)-positive B-cell malignancy corresponds to an aggressive subgroup of atypical chronic lymphocytic leukemia. Leukemia 22, 2123–2127 (2008). https://doi.org/10.1038/leu.2008.102

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