Mini Review

Experimental models of pancreatic cancer desmoplasia

  • Laboratory Investigation 98, 2740 (2018)
  • doi:10.1038/labinvest.2017.127
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Abstract

Desmoplasia is a fibro-inflammatory process and a well-established feature of pancreatic cancer. A key contributor to pancreatic cancer desmoplasia is the pancreatic stellate cell. Various in vitro and in vivo methods have emerged for the isolation, characterization, and use of pancreatic stellate cells in models of cancer-associated fibrosis. In addition to cell culture models, genetically engineered animal models have been established that spontaneously develop pancreatic cancer with desmoplasia. These animal models are currently being used for the study of pancreatic cancer pathogenesis and for evaluating therapeutics against pancreatic cancer. Here, we review various in vitro and in vivo models that are being used or have the potential to be used to study desmoplasia in pancreatic cancer.

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Acknowledgements

We sincerely acknowledge the support provided by the Institute of Life Sciences, Bhubaneswar to SBS; extramural grant by the Department of Biotechnology (DBT), Government of India to SBS (BT/PR13502/MED/30/1555/2015); Senior Research Fellowship by DBT, Government of India to SS and SERB National Post-Doctoral fellowship by the Department of Science and Technology, Government of India to PD. We thank Dr Neera Singh for editing the manuscript.

Author information

Author notes

    • Sujit Suklabaidya
    •  & Pujarini Dash

    These authors have contributed equally to this work.

Affiliations

  1. Tumor Microenvironment and Animal Models Lab, Department of Translational Research, Institute of Life Sciences, Bhubaneswar, Odisha, India

    • Sujit Suklabaidya
    • , Pujarini Dash
    • , Biswajit Das
    • , Voddu Suresh
    •  & Shantibhusan Senapati
  2. Manipal University, Manipal, Karnataka, India

    • Sujit Suklabaidya
    •  & Biswajit Das
  3. Department of General Surgery, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India

    • Prakash K Sasmal

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Competing interests

The authors declare no conflict of interest.

Corresponding author

Correspondence to Shantibhusan Senapati.