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A review of tribromoethanol anesthesia for production of genetically engineered mice and rats

Lab Animal volume 34, pages 4752 (2005) | Download Citation

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Abstract

Tribromoethanol (TBE) is easy and inexpensive to make in the laboratory from readily available reagents, requires no special equipment for its administration, and is not subject to federal or state drug enforcement agency regulations. Intraperitoneal (i.p.) injection of TBE results in the simple and rapid induction of short-term surgical anesthesia; however, recent adverse reports about the efficacy and safety of TBE make its continued routine use as a rodent anesthetic controversial. The authors review the history and use of TBE as an animal anesthetic and conclude that TBE should be relegated to acute terminal studies when administered i.p.

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Author information

Affiliations

  1. Department of Clinical Sciences, College of Veterinary Medicine, PO Box 6100, Mississippi State, MS 39762-6100.

    • Robert E. Meyer DVM, DACVA
  2. Laboratory Animal Resources, College of Veterinary Medicine, Box 8401, North Carolina State University, 4700 Hillsborough St., Raleigh, NC 27606.

    • Richard E. Fish DVM PhD DACLAM

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Robert E. Meyer DVM, DACVA.

About this article

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DOI

https://doi.org/10.1038/laban1105-47

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