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Report of the Working Group on Animal Distress in the Laboratory

Abstract

Finding ways to minimize pain and distress in research animals is a continuing goal in the laboratory animal research field. Pain and distress, however, are not synonymous, and measures that alleviate one may not affect the other. Here, the authors provide a summary of a meeting held in February 2004 that focused on distress in laboratory animals. They discuss the difficulties associated with defining 'distress,' propose methods to aid in recognizing and alleviating distressful conditions, and provide recommendations for animal research conduct and oversight that would minimize distress experienced by laboratory animals.

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References

  1. USDA APHIS AC. Policy #11: Painful and Distressful Procedures. USDA Animal and Plant Health Inspection Animal Care Policy Manuel. (1997) http://www.aphis.usda.gov/ac/policy/policy11.html.

  2. USDA APHIS. Proposed rule. Animal welfare; definitions for and reporting of pain and distress. Federal Register 65(132), 42304–42305 (10 July 2000).

  3. Plous, S. Attitudes toward the use of animals in psychological research and education: results from a national survey of psychologists. Am. Psychol. 51(11), 1167–1180 (1996).

    Article  Google Scholar 

  4. Plous, S. Attitudes toward the use of animals in psychological research and education: results from a national survey of psychology majors. Psychol. Sci. 7, 352–358 (1996).

    Article  Google Scholar 

  5. National Science Board. Science and Engineering Indicators - 2002. (National Science Foundation, Arlington, VA, 2002).

  6. Stephens, M.L. & Conlee, K.M. The HSUS's Pain and Distress Initiative: overview and update. Altern. Lab. Anim. 32(Suppl 1), 423–427 (2004).

    CAS  PubMed  Google Scholar 

  7. HSUS. 2000. Taking Animal Welfare Seriously: Minimizing Pain and Distress in Research Animals. (Animal Research Issues Section, The Humane Society of the United States, Washington, DC). http://www.hsus.org/animals_in_research/pain_distress/ taking_animal_welfare_seriously_minimizing_ pain_and_distress_in_research_animals/index.html.

  8. National Research Council. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research (National Academies Press, Washington, DC, 2003).

  9. Dawkins, M.S. Using behaviour to assess welfare. Anim. Welf. 13(Suppl), S3–S7 (2004).

    CAS  Google Scholar 

  10. Morton, D.B. A systematic approach for establishing humane endpoints. ILAR J. 41(2), 80–86 (2000).

    Article  Google Scholar 

  11. WHO. WHO definition of health. www.who.int/about/definition/en.

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Acknowledgements

The authors thank the Kenneth A. Scott Charitable Trust for providing the necessary funding for this workshop.

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Brown, M., Carbone, L., Conlee, K. et al. Report of the Working Group on Animal Distress in the Laboratory. Lab Anim 35, 26–30 (2006). https://doi.org/10.1038/laban0906-26

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  • DOI: https://doi.org/10.1038/laban0906-26

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