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Effect of intravenous ketamine and lidocaine on isoflurane requirement in sheep undergoing orthopedic surgery

Lab Animal volume 39, pages 76–79 (2010)Cite this article

Abstract

Intravenous ketamine and lidocaine infusions may be useful adjuncts to inhalation anesthesia for sheep undergoing orthopedic surgery. In this study, 50 female sheep underwent experimental stifle surgery (29 received a meniscal implant and 21 received sham surgery). To induce anesthesia in the sheep, the authors intravenously injected ketamine and diazepam. They administered isoflurane in oxygen to maintain anesthesia and used mechanical ventilation to maintain normal arterial carbon dioxide pressure. Some sheep received intravenous infusions of ketamine and lidocaine during surgery, whereas others did not. Sheep that received a meniscal implant without ketamine–lidocaine required ∼23% greater isoflurane concentrations than sheep that were given ketamine–lidocaine. These findings suggest that intravenous infusion of ketamine and lidocaine decreases the requirement for isoflurane during orthopedic surgery on anesthetized sheep.

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Figure 1: ETISO concentrations in sheep undergoing stifle surgery.
Figure 2: MAP in sheep undergoing stifle surgery.

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Author information

Authors and Affiliations

  1. Front Range Community College, Fort Collins, CO

    Tara G Raske

  2. Department of Clinical Sciences, Colorado State University, Fort Collins, CO

    Sheila Pelkey,  Ann E Wagner &  A. Simon Turner

Authors
  1. Tara G Raske
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  2. Sheila Pelkey
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  3. Ann E Wagner
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  4. A. Simon Turner
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Correspondence to Tara G Raske.

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Raske, T., Pelkey, S., Wagner, A. et al. Effect of intravenous ketamine and lidocaine on isoflurane requirement in sheep undergoing orthopedic surgery. Lab Anim 39, 76–79 (2010). https://doi.org/10.1038/laban0310-76

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