Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Clinical Techniques
  • Published:

Altered states part 2: addressing nausea in canine research subjects

Abstract

Nausea and emesis can occur for multiple reasons. While research staff can readily empathize with this type of discomfort, proper assessment and treatment can be challenging. In order to provide optimal care for canine research subjects, it is critical that institutions develop a treatment plan and take preemptive measures to control nausea and emesis when they occur.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Elwood, C. et al. Emesis in dogs: a review. J. Small Anim. Pract. 51, 4–22 (2010).

    Article  CAS  Google Scholar 

  2. Ramsey, D. et al. Cerenia prevents perioperative nausea and vomiting and improves recovery in dogs undergoing routine surgery. Intern. J. Appl. Res. Vet. Med. 12, 228–237 (2014).

    Google Scholar 

  3. Peeters, M.E. & Kirpensteijn, J. Comparison of surgical variables and short-term postoperative complications in healthy dogs undergoing ovariohysterectomy or ovariectomy. J. Am. Vet. Med. Assoc. 238, 189–194 (2011).

    Article  Google Scholar 

  4. Murrell, J.C., Psatha, E.P., Scott, E.M., Reid, J. & Hellebrekers, L.J. Application of a modified form of the Glasgow pain scale in a veterinary teaching centre in the Netherlands. Vet. Rec. 162, 403–408 (2008).

    Article  CAS  Google Scholar 

  5. Morton, C.M., Reid, J., Scott, E.M., Holton, L.L. & Nolan, A.M. Application of a scaling model to establish and validate an interval level pain scale for assessment of acute pain in dogs. Am. J. Vet. Res. 66, 2154–2166 (2005).

    Article  Google Scholar 

  6. Carpenter, R.E., Wilson, D.V. & Evans, A.T. Evaluation of intraperitoneal and incisional lidocaine or bupivacaine for analgesia following ovariohysterectomy in the dog. Vet. Anaesth. Analg. 31, 46–52 (2004).

    Article  CAS  Google Scholar 

  7. Norred, C.L. Antiemetic prophylaxis; pharmacology and therapeutics. AANA J. 71, 133–141 (2003).

    PubMed  Google Scholar 

  8. Ramsey D.S. et al. Safety and efficacy of injectable and oral maropitant, a selective neurokinin 1 receptor antagonist, in a randomized clinical trial for treatment of vomiting in dogs. J. Vet. Pharmacol. Ther. 31, 538–543 (2008).

    Article  CAS  Google Scholar 

  9. Conder, G.A., Sedlacek, H.S., Boucher, J.F. & Clemence, R.G. Efficacy and safety of maropitant, a selective neurokinin 1 receptor antagonist, in two randomized clinical trials for prevention of vomiting due to motion sickness in dogs. J. Vet. Pharmacol. Ther. 31, 528–532 (2008).

    Article  CAS  Google Scholar 

  10. Benchaoui, H.A. et al. Efficacy of maropitant for preventing vomiting associated with motion sickness in dogs. Vet Rec. 161, 444–447 (2007).

    Article  CAS  Google Scholar 

  11. de la Puente-Redondo, V.A. et al. The antiemetic efficacy of maropitant (Cerenia) in the treatment of ongoing emesis caused by a wide range of underlying clinical aetiologies in canine patients in Europe. J. Small. Anim. Pract. 48, 93–98 (2007).

    Article  CAS  Google Scholar 

  12. US Food and Drug Administration. Original New Animal Drug Application: Cerenia. (US Food and Drug Administration, Silver Spring, MD, 2007) http://www.fda.gov/downloads/AnimalVeterinary/Products/ApprovedAnimalDrug Products/FOIADrugSummaries/UCM050060.pdf

  13. Plumb, D.C. Plumb Veterinary Drug Handbook. 8th ed. (Wiley-Blackwell, Ames, 2008).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Victoria Hampshire.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hampshire, V. Altered states part 2: addressing nausea in canine research subjects. Lab Anim 45, 61–62 (2016). https://doi.org/10.1038/laban.931

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/laban.931

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing