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Blood biochemical changes in pigs after infusion with acetate-buffered or lactate-buffered crystalloid solutions

Lab Animal volume 44, pages 268–273 (2015)Cite this article

Abstract

Perioperative fluid therapy is an important component of many medical procedures with animals. Buffered crystalloid solutions avoid inducing metabolic acidosis, but lactated solutions can elevate blood lactate concentrations and acetated solutions have not been thoroughly investigated using large animals. Here, the authors compare blood biochemical parameters in 20 juvenile pigs after perioperative fluid administration of an acetate-buffered solution (Elo-Mel isoton, EMI) or a lactate-buffered solution (lactated Ringer's solution, LRS). The authors measured blood lactate, glucose and electrolyte concentrations before and after administering the test fluid during surgery. Blood lactate concentration after administration was significantly higher in pigs that received LRS than in pigs that received EMI, but glucose and electrolyte concentrations did not differ significantly between treatment groups before or after administration. These findings suggest that EMI might be a preferable option for perioperative fluid therapy in pigs.

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Figure 1: Blood lactate concentration before and after infusion of lactate-buffered (LRS) or acetate-buffered (EMI) crystalloid solution.

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Authors and Affiliations

  1. Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Austrian Cluster for Tissue Regeneration, Vienna, Austria

    Claudia Keibl,  Martin Ponschab &  Christoph J. Schlimp

  2. Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, Vienna, Austria

    Wolfgang Sipos

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  1. Claudia Keibl
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  4. Christoph J. Schlimp
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Correspondence to Claudia Keibl.

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Keibl, C., Sipos, W., Ponschab, M. et al. Blood biochemical changes in pigs after infusion with acetate-buffered or lactate-buffered crystalloid solutions. Lab Anim 44, 268–273 (2015). https://doi.org/10.1038/laban.739

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