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Comparison of silicone and polyurethane catheters for the catheterization of small vessels in mice

Lab Animal volume 43, pages 397403 (2014) | Download Citation

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Abstract

Vascular catheterization is increasingly carried out in laboratory mice, but the long-term patency of catheters implanted in mice is limited owing to their small size. The authors compared mice that were catheterized in their right common carotid artery either with a silicone catheter with a polyurethane tip or with a 100% polyurethane catheter to determine which catheter type was better suited for long-term studies in mice. The catheters were inspected daily and were flushed if blood was visible in the catheters; if no blood was visible, they were flushed every 3 d. Silicone catheters were patent for a shorter period of time than polyurethane catheters, which were patent for a median of 6 d and up to 25 d. The authors identify the principal causes of catheter failure and discuss how they can be prevented.

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Acknowledgements

We thank Otto Kalliokoski for thoroughly reading and commenting on the manuscript.

Author information

Author notes

    • Anne Charlotte Teilmann
    •  & Malene Kari Falkenberg

    These authors contributed equally to this work.

Affiliations

  1. Department of Experimental Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

    • Anne Charlotte Teilmann
    • , Malene Kari Falkenberg
    • , Jann Hau
    •  & Klas Stig Peter Abelson

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The authors declare no competing financial interests.

Corresponding author

Correspondence to Anne Charlotte Teilmann.

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DOI

https://doi.org/10.1038/laban.570