SCIENTIFIC NAME Marmota monax
TAXONOMY PHYLUM: Chordata CLASS: Mammalia ORDER: Rodentia FAMILY: Sciuridae
The woodchuck, also called groundhog, land beaver, mouse bear or whistle-pig, is a type of marmot or large ground squirrel found primarily in lowland areas of North America. Its short, strong limbs and curved, thick claws are well-suited to digging and burrowing, one of the woodchuck's main activities in the wild. It also sports rounded ears that can close off the ear canal to prevent dirt and debris from entering it while burrowing underground.
Woodchucks sleep, care for their young and hibernate underground, and their burrows can be vast, with tunnels extending more than 15 m in length and including multiple access points. It has been estimated that a woodchuck displaces over 300 kg of soil in digging an average burrow. In residential and agricultural areas, woodchuck burrows are considered a nuisance or even a hazard, as they can destroy crops, damage farming equipment and compromise building foundations1. But they can have unexpected benefits too. Woodchuck burrows in Ohio have turned up numerous historical artifacts, including bones, pottery and pieces of stone, leading to the identification of an archaeological site called the Ufferman Site2.
Woodchucks have been used to study a broad range of biomedical research topics including obesity and energy balance, endocrine and metabolic function, central nervous system control mechanisms, and cardiovascular and cerebrovascular disease3. They are also commonly used in hibernation research. One recent study examined the mechanisms that protect cardiac function during hibernation in woodchucks in hopes of gaining information that could help to prevent cardiac dysfunction resulting from hypothermic stress and myocardial ischemia in humans4. The 'optimization' of hibernation strategies—balancing the physiological and ecological costs against the benefits—has also been examined in woodchucks. Researchers found that woodchucks' body mass correlated positively with body temperature during torpor and correlated negatively with the fraction of time spent in torpor, meaning that larger woodchucks spent less time in torpor and at higher body temperatures than smaller woodchucks5. The scientists suggest that this strategy may improve the woodchucks' chances of success in defending territories, avoiding predators and reproducing when they emerge from hibernation.
The biggest contribution woodchucks have made to biomedical research is arguably in the area of hepatitis and liver cancer. Woodchucks are naturally susceptible to infection with hepatitis virus. Once infected, they develop liver cancer. This pattern is very similar to hepatitis B virus infection and subsequent development of hepatocellular carcinoma in humans, making the woodchuck a valuable model for investigating virology, immunology and treatment of these diseases6. The woodchuck model has provided insight into the roles of persistent hepatitis virus infection, viral load and host immune response in chronic hepatitis and hepatocellular carcinoma7. The model is also suitable for evaluating the safety and efficacy of candidate drugs and experimental vaccines for treating and preventing the diseases that result from hepatitis virus infection7. Initial studies relied on wild-caught woodchucks, but since then, breeding colonies have been established in laboratories; both wild-caught and captive-born woodchucks are also available commercially (http://www.northeasternwildlife.com/).
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Harrington, M. What a woodchuck could chuck. Lab Anim 43, 117 (2014). https://doi.org/10.1038/laban.516