Abstract
Objective:
To assess the accuracy of different sonographic estimated fetal weight (EFW) cutoffs, and combinations of EFW and biometric measurements for predicting small for gestational age (SGA) in fetal gastroschisis.
Study Design:
Gastroschisis cases from two centers were included. The sensitivity, specificity, positive and negative predictive values (PPV and NPV) were calculated for different EFW cutoffs, as well as EFW and biometric measurement combinations.
Results:
Seventy gastroschisis cases were analyzed. An EFW<10% had 94% sensitivity, 43% specificity, 33% PPV and 96% NPV for SGA at delivery. Using an EFW cutoff of <5% improved the specificity to 63% and PPV to 41%, but decreased the sensitivity to 88%. Combining an abdominal circumference (AC) or femur length (FL) z-score less than −2 with the total EFW improved the specificity and PPV but decreased the sensitivity.
Conclusion:
A combination of a small AC or FL along with EFW increases the specificity and PPV, but decreases the sensitivity of predicting SGA.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Kirby RS, Marshall J, Tanner JP, Salemi JL, Feldkamp ML, Marengo L et al. Prevalence and correlates of gastroschisis in 15 states, 1995 to 2005. Obstet Gynecol 2013; 122 (2 Pt 1): 275–281.
Girsen AI, Do S, Davis AS, Hintz SR, Desai AK, Mansour T et al. Peripartum and neonatal outcomes of small-for-gestational-age infants with gastroschisis. Prenat Diagn 2015; 35 (5): 477–482.
Payne NR, Simonton SC, Olsen S, Arnesen MA, Pfleghaar KM . Growth restriction in gastroschisis: quantification of its severity and exploration of a placental cause. BMC Pediatr 2011; 11: 90.
Nelson DB, Martin R, Twickler DM, Santiago-Munoz PC, McIntire DD, Dashe JS . Sonographic detection and clinical importance of growth restriction in pregnancies with gastroschisis. J Ultrasound Med 2015; 34 (12): 2217–2223.
Ajayi FA, Carroll PD, Shellhaas C, Foy P, Corbitt R, Osawe O et al. Ultrasound prediction of growth abnormalities in fetuses with gastroschisis. J Matern Fetal Neonatal Med 2011; 24 (3): 489–492.
Chaudhury P, Haeri S, Horton AL, Wolfe HM, Goodnight WH . Ultrasound prediction of birthweight and growth restriction in fetal gastroschisis. Am J Obstet Gynecol 2010; 203 (4): 395 e1–395 e5.
Santiago-Munoz PC, McIntire DD, Barber RG, Megison SM, Twickler DM, Dashe JS . Outcomes of pregnancies with fetal gastroschisis. Obstet Gynecol 2007; 110 (3): 663–668.
Lammer EJ, Iovannisci DM, Tom L, Schultz K, Shaw GM . Gastroschisis: a gene-environment model involving the VEGF-NOS3 pathway. Am J Med Genet C Semin Med Genet 2008; 148C (3): 213–218.
Chen IL, Lee SY, Ou-Yang MC, Chao PH, Liu CA, Chen FS et al. Clinical presentation of children with gastroschisis andsmall for gestational age. Pediatr Neonatol 2011; 52 (4): 219–222.
Adams SR, Durfee S, Pettigrew C, Katz D, Jennings R, Ecker J et al. Accuracy of sonography to predict estimated weight in fetuses with gastroschisis. J Ultrasound Med 2012; 31 (11): 1753–1758.
Nicholas S, Tuuli MG, Dicke J, Macones GA, Stamilio D, Odibo AO . Estimation of fetal weight in fetuses with abdominal wall defects: comparison of 2 recent sonographic formulas to the Hadlock formula. J Ultrasound Med 2010; 29 (7): 1069–1074.
Hadlock FP, Deter RL, Harrist RB, Park SK . Estimating fetal age: computer-assisted analysis of multiple fetal growth parameters. Radiology 1984; 152 (2): 497–501.
Hadlock FP, Harrist RB, Martinez-Poyer J . In utero analysis of fetal growth: a sonographic weight standard. Radiology 1991; 181 (1): 129–133.
Hadlock FP, Harrist RB, Sharman RS, Deter RL, Park SK . Estimation of fetal weight with the use of head, body, and femur measurements—a prospective study. Am J Obstet Gynecol 1985; 151 (3): 333–337.
Fenton TR . A new growth chart for preterm babies: Babson and Benda's chart updated with recent data and a new format. BMC Pediatr 2003; 3: 13.
Centofanti SF, Brizot Mde L, Liao AW, Francisco RP, Zugaib M . Fetal growth pattern and prediction of low birth weight in gastroschisis. Fetal Diagn Ther 2015; 38 (2): 113–118.
Harris EL, Minutillo C, Hart S, Warner TM, Ravikumara M, Nathan EA et al. The long term physical consequences of gastroschisis. J Pediatr Surg 2014; 49 (10): 1466–1470.
Cain MA, Salemi JL, Paul Tanner J, Mogos MF, Kirby RS, Whiteman VE et al. Perinatal outcomes and hospital costs in gastroschisis based on gestational age at delivery. Obstet Gynecol 2014; 124 (3): 543–550.
Overcash RT, DeUgarte DA, Stephenson ML, Gutkin RM, Norton ME, Parmar S et al. Factors associated with gastroschisis outcomes. Obstet Gynecol 2014; 124 (3): 551–557.
Martillotti G, Boucoiran I, Damphousse A, Grignon A, Dube E, Moussa A et al. Predicting perinatal outcome from prenatal ultrasound characteristics in pregnancies complicated by gastroschisis. Fetal Diagn Ther 2015; 39 (4): 279–286.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Additional information
The study was presented at the 36th Annual Meeting of the Society for Maternal–Fetal Medicine, Atlanta, GA, February 2016.
Rights and permissions
About this article
Cite this article
Blumenfeld, Y., Do, S., Girsen, A. et al. Utility of third trimester sonographic measurements for predicting SGA in cases of fetal gastroschisis. J Perinatol 37, 498–501 (2017). https://doi.org/10.1038/jp.2016.275
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/jp.2016.275