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Breakthrough in the prevention of mother-to-child hepatitis B transmission?

Manuscript Citation: Pan, et al. “Tenofovir to Prevent Hepatitis B Transmission in Mothers with High Viral Load.” N Engl J Med 2016; 374:2324-2334.

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References

  1. Goldstein ST, Zhou F, Hadler SC, Bell BP, Mast EE, Margolis HS . A mathematical model to estimate global hepatitis B disease burden and vaccination impact. Int J Epidemiol 2005; 34 (6): 1329–1339.

    Article  Google Scholar 

  2. Society for Maternal-Fetal M Society for Maternal-Fetal M, Dionne-Odom J, Society for Maternal-Fetal M, Tita AT, Society for Maternal-Fetal M, Silverman NS . #38: Hepatitis B in pregnancy screening, treatment, and prevention of vertical transmission. Am J Obstetr Gynecol 2016; 214 (1): 6–14.

    Article  Google Scholar 

  3. Zou H, Chen Y, Duan Z, Zhang H, Pan C . Virologic factors associated with failure to passive-active immunoprophylaxis in infants born to HBsAg-positive mothers. J Viral Hepat 2012; 19 (2): e18–e25.

    Article  CAS  Google Scholar 

  4. Pan CQ, Duan Z, Dai E, Zhang S, Han G, Wang Y et al. Tenofovir to prevent hepatitis B transmission in mothers with high viral load. N Engl J Med 2016; 374 (24): 2324–2334.

    Article  CAS  Google Scholar 

  5. Nayeri UA, Werner EF, Han CS, Pettker CM, Funai EF, Thung SF . Antenatal lamivudine to reduce perinatal hepatitis B transmission: a cost-effectiveness analysis. Am J Obstetr Gynecol 2012; 207 (3): 231 e231–231 e237.

    Article  Google Scholar 

  6. Xu WM, Cui YT, Wang L, Yang H, Liang ZQ, Li XM et al. Lamivudine in late pregnancy to prevent perinatal transmission of hepatitis B virus infection: a multicentre, randomized, double-blind, placebo-controlled study. J Viral Hepat 2009; 16 (2): 94–103.

    Article  Google Scholar 

  7. Brown RS Jr, McMahon BJ, Lok AS, Wong JB, Ahmed AT, Mouchli MA et al. Antiviral therapy in chronic hepatitis B viral infection during pregnancy: a systematic review and meta-analysis. Hepatology 2016; 63 (1): 319–333.

    Article  CAS  Google Scholar 

  8. Benaboud S, Pruvost A, Coffie PA, Ekouévi DK, Urien S, Arrivé E et al. Concentrations of tenofovir and emtricitabine in breast milk of HIV-1-infected women in Abidjan, Cote d'Ivoire, in the ANRS 12109 TEmAA Study, Step 2. Antimicrob Agents Chemother 2011; 55 (3): 1315–1317.

    Article  CAS  Google Scholar 

  9. World Health Organization. Guidelines for the Prevention, Care and Treatment of Persons with Chronic Hepatitis B Infection. WHO: Geneva, 2015.

  10. Thio CL, Guo N, Xie C, Nelson KE, Ehrhardt S . Global elimination of mother-to-child transmission of hepatitis B: revisiting the current strategy. Lancet Infect Dis 2015; 15 (8): 981–985.

    Article  Google Scholar 

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Correspondence to E P Masoumy.

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Masoumy, E., Stansfield, B. Breakthrough in the prevention of mother-to-child hepatitis B transmission?. J Perinatol 37, 333–334 (2017). https://doi.org/10.1038/jp.2016.269

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