A comparison of 7-day versus 10-day course of low-dose dexamethasone for chronically ventilated preterm infants

Abstract

Objective:

The objective of the study was to compare the effect of two different dexamethasone regimens on respiratory outcomes of ventilator-dependent preterm infants.

Study Design:

Retrospective study of ventilated preterm infants <29 weeks gestational age treated with either 7-day or 10-day dexamethasone course. Primary outcome was days to successful extubation. Other outcomes included rate of successful extubation and need for repeat steroid therapy.

Results:

Fifty-nine infants were identified; 32 (54%) received 7 days of dexamethasone and 27 (46%) received 10 days of dexamethasone. Both groups had comparable baseline demographics and clinical characteristics. Mean time to successful extubation was similar between the two groups (5.1±2.7 days in 7-day group and 6.0±3.7 days in 10-day group, P=0.42). Successful extubation by end of treatment (56% versus 67%, P=0.44) and need for repeat steroid therapy (47% versus 33%, P=0.43) were also similar.

Conclusion:

7-day and 10-day course of dexamethasone have comparable efficacy in facilitating extubation of ventilator-dependent preterm infants.

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Acknowledgements

We would like to thank the Medical Writing Center at Children’s Mercy Kansas City for their assistance in proofreading and editing this manuscript.

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Correspondence to A Cuna.

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The authors declare no conflict of interest.

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Cuna, A., Govindarajan, S., Oschman, A. et al. A comparison of 7-day versus 10-day course of low-dose dexamethasone for chronically ventilated preterm infants. J Perinatol 37, 301–305 (2017) doi:10.1038/jp.2016.215

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