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Does chronic oxygen dependency in preterm infants with bronchopulmonary dysplasia at NICU discharge predict respiratory outcomes at 3 years of age?

Journal of Perinatology volume 35, pages 530–536 (2015)Cite this article

Subjects

Abstract

Objective:

To determine whether chronic oxygen dependency at the time of discharge from the neonatal intensive care unit (NICU) in infants with bronchopulmonary dysplasia (BPD) predicts respiratory outcomes at 3 years.

Study design:

Preterm infants ⩽1250 g without BPD, BPD and BPD with chronic oxygen dependency were identified from the Southern Alberta Perinatal Follow-up clinic database (1995–2007). Respiratory outcomes at 4, 8, 18 and 36 months corrected age following NICU discharge were examined. Univariate analyses were done.

Results:

Out of 1563 infants admitted to the NICU, 1212 survived. Complete follow-up data at 36 months were available for 1030 (85%) children. Children with BPD with or without chronic oxygen dependency had significantly (P<0.001) lower birth weights and gestational ages, and greater post-natal steroid use, compared with those with no BPD. At 4, 8 and 18 months follow-up, the use of respiratory medications and supplemental oxygen were both significantly higher in the BPD infants with chronic oxygen dependency group compared with the no-BPD group and BPD group. At 36 months, children in the BPD with chronic oxygen dependency group were more likely to use respiratory medications and supplemental oxygen vs the no-BPD or the BPD groups. At 4, 8 and 36 months of age, more children in the BPD with chronic oxygen dependency group had post-neonatal chronic lung disease (PNCLD) than children in the other groups, but at 36 months the difference was significant only for the BPD with chronic oxygen dependency vs no-BPD group (P<0.001).

Conclusions:

At 36 months, children diagnosed with BPD with chronic oxygen dependency at NICU discharge were more likely to need respiratory medications and supplemental oxygen in the previous 12 months, as compared with no-BPD or BPD groups. They were also more likely to require frequent physician visits and have PNCLD at 3 years, as compared with the no-BPD group.

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Authors and Affiliations

  1. Department of Pediatrics, University of Calgary, Calgary, Alberta, Canada

    A Lodha, K Ediger, Y Rabi, S Lodha & R Sauve

  2. Department of Pediatrics, Alberta Children's Hospital Research Institute, Calgary, Alberta, Canada

    A Lodha, Y Rabi & R Sauve

  3. Department of Pediatrics, Alberta Health Services, Calgary, Alberta, Canada

    A Lodha, Y Rabi, S Tang & R Sauve

  4. Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada

    A Lodha

  5. Department of Pediatric Pulmonology, Connecticut Children's Medical Center, Hartford, CT, USA

    A Bhandari

  6. Department of Pediatrics, Yale University, New Haven, CT, USA

    V Bhandari

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  1. A Lodha
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Correspondence to V Bhandari.

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Lodha, A., Ediger, K., Rabi, Y. et al. Does chronic oxygen dependency in preterm infants with bronchopulmonary dysplasia at NICU discharge predict respiratory outcomes at 3 years of age?. J Perinatol 35, 530–536 (2015). https://doi.org/10.1038/jp.2015.7

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